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Automated radiosynthesis of [11C]MTP38—a phosphodiesterase 7 imaging tracer—using [11C]hydrogen cyanide for clinical applications
https://repo.qst.go.jp/records/85665
https://repo.qst.go.jp/records/85665c278aef8-7334-4d0c-9716-7081baa449fd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-01-31 | |||||
| タイトル | ||||||
| タイトル | Automated radiosynthesis of [11C]MTP38—a phosphodiesterase 7 imaging tracer—using [11C]hydrogen cyanide for clinical applications | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kazunori, Kawamura
× Kazunori, Kawamura× Hiroki, Hashimoto× Ohkubo, Takayuki× Masayuki, Hanyu× Masanao, Ogawa× Nobuki, Nengaki× Daisuke, Arashi× Kurihara, Yusuke× Fujishiro, Tomoya× Togashi, Takahiro× Sakai, Toshiyuki× Masatoshi, Muto× Makoto, Takei× Hideki, Ishii× Takeaki, Saijo× Takehiko, Matsumura× Naoyuki, Obokata× Zhang, Ming-Rong× Kazunori, Kawamura× Hiroki, Hashimoto× Ohkubo, Takayuki× Masayuki, Hanyu× Masanao, Ogawa× Nobuki, Nengaki× Daisuke, Arashi× Kurihara, Yusuke× Fujishiro, Tomoya× Togashi, Takahiro× Sakai, Toshiyuki× Masatoshi, Muto× Makoto, Takei× Hideki, Ishii× Naoyuki, Obokata× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3- a]pyrazine-5-[11C]carbonitrile ([11C]MTP38) as a PET tracer for the imaging of phosphodiesterase 7. For the fully automated production of [11C]MTP38 routinely and efficiently for clinical applications, we determined the radiosynthesis procedure of [11C]MTP38 using [11C]hydrogen cyanide ([11C]HCN) as a PET radiopharmaceutical. Radiosynthesis of [11C]MTP38 was performed using an automated 11C-labeling synthesizer developed in-house within 40 min after the end of irradiation. [11C]MTP38 was obtained with a relatively high radiochemical yield (33 ± 5.5% based on [11C]CO 2 at the end of irradiation, decay-corrected, n = 15), radiochemical purity (>97%, n = 15), and molar activity (47 ± 12 GBq/µmol at the end of synthesis, n = 15). All the results of the quality control (QC) testing for the [11C]MTP38 injection complied with our in-house QC and quality assurance specifications. We successfully automated the radiosynthesis of [11C]MTP38 for clinical applications using an 11C-labeling synthesizer and sterile isolator. Taken together, this protocol provides a new radiopharmaceutical [11C]MTP38 suitable for clinical applications. |
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| 書誌情報 |
Journal of Labelled Compounds and Radiopharmaceuticals 巻 65, 号 5, p. 140-146, 発行日 2022-02 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35122288 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jlcr.3965 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jlcr.3965 | |||||
