@article{oai:repo.qst.go.jp:00085665,
 author = {Kazunori, Kawamura and Hiroki, Hashimoto and Ohkubo, Takayuki and Masayuki, Hanyu and Masanao, Ogawa and Nobuki, Nengaki and Daisuke, Arashi and Kurihara, Yusuke and Fujishiro, Tomoya and Togashi, Takahiro and Sakai, Toshiyuki and Masatoshi, Muto and Makoto, Takei and Hideki, Ishii and Takeaki, Saijo and Takehiko, Matsumura and Naoyuki, Obokata and Zhang, Ming-Rong and Kazunori, Kawamura and Hiroki, Hashimoto and Ohkubo, Takayuki and Masayuki, Hanyu and Masanao, Ogawa and Nobuki, Nengaki and Daisuke, Arashi and Kurihara, Yusuke and Fujishiro, Tomoya and Togashi, Takahiro and Sakai, Toshiyuki and Masatoshi, Muto and Makoto, Takei and Hideki, Ishii and Naoyuki, Obokata and Zhang, Ming-Rong},
 issue = {5},
 journal = {Journal of Labelled Compounds and Radiopharmaceuticals},
 month = {Feb},
 note = {We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3-
a]pyrazine-5-[11C]carbonitrile ([11C]MTP38) as a PET tracer for the imaging of 
phosphodiesterase 7. For the fully automated production of [11C]MTP38 routinely and efficiently for clinical applications, we determined the radiosynthesis procedure of [11C]MTP38 using [11C]hydrogen cyanide ([11C]HCN) as a PET radiopharmaceutical. Radiosynthesis of [11C]MTP38 was performed using an automated 11C-labeling synthesizer developed in-house within 40 min after the end of irradiation. [11C]MTP38 was obtained with a relatively high radiochemical yield (33 ± 5.5% based on [11C]CO 2 at the end of irradiation, decay-corrected, n = 15), radiochemical purity (>97%, n = 15), and molar activity (47 ± 12 GBq/µmol at the end of synthesis, n = 15). All the results of the quality control (QC) testing for the [11C]MTP38 injection complied with our in-house QC and quality assurance specifications. We successfully automated the radiosynthesis of [11C]MTP38 for clinical applications using an 11C-labeling synthesizer and sterile isolator. Taken together, this protocol provides a new radiopharmaceutical [11C]MTP38 suitable for clinical applications.},
 pages = {140--146},
 title = {Automated radiosynthesis of [11C]MTP38—a  phosphodiesterase 7 imaging tracer—using [11C]hydrogen  cyanide for clinical applications},
 volume = {65},
 year = {2022}
}