{"created":"2023-05-15T15:03:14.407068+00:00","id":85665,"links":{},"metadata":{"_buckets":{"deposit":"6caf2988-8800-4abe-b2bd-f0b47bb9bb00"},"_deposit":{"created_by":1,"id":"85665","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85665"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085665","sets":["1"]},"author_link":["1046551","1046528","1046552","1046527","1046535","1046529","1046542","1046557","1046540","1046548","1046539","1046526","1046537","1046543","1046547","1046545","1046546","1046556","1046549","1046534","1046538","1046525","1046536","1046530","1046554","1046544","1046532","1046541","1046533","1046531","1046553","1046555","1046558","1046550"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"146","bibliographicPageStart":"140","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Journal of Labelled Compounds and Radiopharmaceuticals"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3-\na]pyrazine-5-[11C]carbonitrile ([11C]MTP38) as a PET tracer for the imaging of \nphosphodiesterase 7. For the fully automated production of [11C]MTP38 routinely and efficiently for clinical applications, we determined the radiosynthesis procedure of [11C]MTP38 using [11C]hydrogen cyanide ([11C]HCN) as a PET radiopharmaceutical. Radiosynthesis of [11C]MTP38 was performed using an automated 11C-labeling synthesizer developed in-house within 40 min after the end of irradiation. [11C]MTP38 was obtained with a relatively high radiochemical yield (33 ± 5.5% based on [11C]CO 2 at the end of irradiation, decay-corrected, n = 15), radiochemical purity (>97%, n = 15), and molar activity (47 ± 12 GBq/µmol at the end of synthesis, n = 15). All the results of the quality control (QC) testing for the [11C]MTP38 injection complied with our in-house QC and quality assurance specifications. We successfully automated the radiosynthesis of [11C]MTP38 for clinical applications using an 11C-labeling synthesizer and sterile isolator. Taken together, this protocol provides a new radiopharmaceutical [11C]MTP38 suitable for clinical applications.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35122288","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/jlcr.3965","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jlcr.3965","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0362-4803","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kazunori, Kawamura"}],"nameIdentifiers":[{"nameIdentifier":"1046525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroki, Hashimoto"}],"nameIdentifiers":[{"nameIdentifier":"1046526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"1046527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu"}],"nameIdentifiers":[{"nameIdentifier":"1046528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanao, Ogawa"}],"nameIdentifiers":[{"nameIdentifier":"1046529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuki, Nengaki"}],"nameIdentifiers":[{"nameIdentifier":"1046530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daisuke, Arashi"}],"nameIdentifiers":[{"nameIdentifier":"1046531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"1046532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujishiro, Tomoya"}],"nameIdentifiers":[{"nameIdentifier":"1046533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Togashi, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"1046534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"1046535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masatoshi, Muto"}],"nameIdentifiers":[{"nameIdentifier":"1046536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Takei"}],"nameIdentifiers":[{"nameIdentifier":"1046537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideki, Ishii"}],"nameIdentifiers":[{"nameIdentifier":"1046538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeaki, Saijo"}],"nameIdentifiers":[{"nameIdentifier":"1046539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takehiko, Matsumura"}],"nameIdentifiers":[{"nameIdentifier":"1046540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoyuki, Obokata"}],"nameIdentifiers":[{"nameIdentifier":"1046541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1046542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroki, Hashimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanao, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuki, Nengaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daisuke, Arashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujishiro, Tomoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Togashi, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Toshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masatoshi, Muto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Takei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideki, Ishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoyuki, Obokata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046558","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Automated radiosynthesis of [11C]MTP38—a  phosphodiesterase 7 imaging tracer—using [11C]hydrogen  cyanide for clinical applications","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Automated radiosynthesis of [11C]MTP38—a  phosphodiesterase 7 imaging tracer—using [11C]hydrogen  cyanide for clinical applications"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-31"},"publish_date":"2022-01-31","publish_status":"0","recid":"85665","relation_version_is_last":true,"title":["Automated radiosynthesis of [11C]MTP38—a  phosphodiesterase 7 imaging tracer—using [11C]hydrogen  cyanide for clinical applications"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:13:54.984231+00:00"}