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MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors.
https://repo.qst.go.jp/records/85430
https://repo.qst.go.jp/records/85430e7cf6cf2-5da7-430d-b7a4-3f6d1f6edc5a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-23 | |||||
| タイトル | ||||||
| タイトル | MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Satoshi
× Okada, Satoshi× Takayasu, Satoko× Sumiyoshi, Akira× Aoki, Ichio× Nakamura, Hiroyuki× Akira, Sumiyoshi× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Glucose sensors for NMR relaxometry and magnetic resonance imaging (MRI) can be used for the direct measurement of glucose in turbid biological specimens. Here, we proposed a magnetic glucose sensor based on superparamagnetic iron oxide (SPIO) nanoparticles conjugated to a mannopyranoside derivative and concanavalin A (ConA). The binding of mannopyranoside groups to ConA produced a nanoparticle cluster that was dissociated by competitive binding of glucose to ConA, resulting in changes in the transverse relaxation time (T) in a glucose-dependent manner. The sensor gave rise to significant T changes in physiological glucose levels of 3 - 8 mM at a nanoparticle concentration of 0.5 nM. Significant T responses were observed within 6 min of 5 mM glucose detection. Sensor-based MRI by a benchtop 1 tesla scanner permitted a measurement of multiple samples within 8 min. These results demonstrate that the relaxometric glucose sensor could lead to high throughput direct assay of blood samples by using a compact MRI scanner for point-of-care testing. | |||||
| 書誌情報 |
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 巻 37, 号 12, p. 1765-1769-1769, 発行日 2021-12 |
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| 出版者 | ||||||
| 出版者 | Japan Society For Analytical Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0910-6340 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34248090 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2116/analsci.21P082 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/analsci/37/12/37_21P082/_article/-char/ja/ | |||||
