@article{oai:repo.qst.go.jp:00085430,
 author = {Okada, Satoshi and Takayasu, Satoko and Sumiyoshi, Akira and Aoki, Ichio and Nakamura, Hiroyuki and Akira, Sumiyoshi and Ichio, Aoki},
 issue = {12},
 journal = {Analytical sciences : the international journal of the Japan Society for Analytical Chemistry},
 month = {Dec},
 note = {Glucose sensors for NMR relaxometry and magnetic resonance imaging (MRI) can be used for the direct measurement of glucose in turbid biological specimens. Here, we proposed a magnetic glucose sensor based on superparamagnetic iron oxide (SPIO) nanoparticles conjugated to a mannopyranoside derivative and concanavalin A (ConA). The binding of mannopyranoside groups to ConA produced a nanoparticle cluster that was dissociated by competitive binding of glucose to ConA, resulting in changes in the transverse relaxation time (T) in a glucose-dependent manner. The sensor gave rise to significant T changes in physiological glucose levels of 3 - 8 mM at a nanoparticle concentration of 0.5 nM. Significant T responses were observed within 6 min of 5 mM glucose detection. Sensor-based MRI by a benchtop 1 tesla scanner permitted a measurement of multiple samples within 8 min. These results demonstrate that the relaxometric glucose sensor could lead to high throughput direct assay of blood samples by using a compact MRI scanner for point-of-care testing.},
 pages = {1765-1769--1769},
 title = {MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors.},
 volume = {37},
 year = {2021}
}