{"created":"2023-05-15T15:03:03.698389+00:00","id":85430,"links":{},"metadata":{"_buckets":{"deposit":"98197097-cca5-43eb-8bbc-f184fb38d35e"},"_deposit":{"created_by":1,"id":"85430","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85430"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085430","sets":["1"]},"author_link":["1029447","1029446","1029449","1029445","1029451","1029450","1029448"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1769","bibliographicPageStart":"1765-1769","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Glucose sensors for NMR relaxometry and magnetic resonance imaging (MRI) can be used for the direct measurement of glucose in turbid biological specimens. Here, we proposed a magnetic glucose sensor based on superparamagnetic iron oxide (SPIO) nanoparticles conjugated to a mannopyranoside derivative and concanavalin A (ConA). The binding of mannopyranoside groups to ConA produced a nanoparticle cluster that was dissociated by competitive binding of glucose to ConA, resulting in changes in the transverse relaxation time (T) in a glucose-dependent manner. The sensor gave rise to significant T changes in physiological glucose levels of 3 - 8 mM at a nanoparticle concentration of 0.5 nM. Significant T responses were observed within 6 min of 5 mM glucose detection. Sensor-based MRI by a benchtop 1 tesla scanner permitted a measurement of multiple samples within 8 min. These results demonstrate that the relaxometric glucose sensor could lead to high throughput direct assay of blood samples by using a compact MRI scanner for point-of-care testing.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Society For Analytical Chemistry"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34248090","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2116/analsci.21P082","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/analsci/37/12/37_21P082/_article/-char/ja/","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0910-6340","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okada, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"1029445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takayasu, Satoko"}],"nameIdentifiers":[{"nameIdentifier":"1029446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sumiyoshi, Akira"}],"nameIdentifiers":[{"nameIdentifier":"1029447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"1029448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"1029449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akira, Sumiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1029450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1029451","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-23"},"publish_date":"2021-12-23","publish_status":"0","recid":"85430","relation_version_is_last":true,"title":["MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:49:47.651878+00:00"}