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Amino Acid Derivative Design Using Computational Chemistry and Application to PET Tracer
https://repo.qst.go.jp/records/85333
https://repo.qst.go.jp/records/85333f85723f7-63af-4789-9691-adccfe78ba9d
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-01-05 | |||||
| タイトル | ||||||
| タイトル | Amino Acid Derivative Design Using Computational Chemistry and Application to PET Tracer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hiroshi, Yamaguchi
× Hiroshi, Yamaguchi× Yamashiro, Keiichi× Maki, Okada× Karuo, Yukiko× Omote, Masaaki× Kato, Katsuhiko× Hiroshi, Yamaguchi× Maki, Okada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We developed a positron emission tomography (PET) imaging agent for glutamate transporter (GLT). Direct labeling of glutamic acid enables in vivo observation of amino acid displacement. However, the high permeability of GLT to amino acids makes imaging challenging. This is because direct PET nuclide-labeled amino acids do not bind to transporters. Additionally, excessive modification impedes blood–brain barrier (BBB) permeability. Hence, we report the derivatization of a glutamate molecule and the introduction of a PET nuclide using computational chemistry. | |||||
| 書誌情報 |
Peptide Science p. 31-34, 発行日 2021-02 |
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