@inproceedings{oai:repo.qst.go.jp:00085333,
 author = {Hiroshi, Yamaguchi and Yamashiro, Keiichi and Maki, Okada and Karuo, Yukiko and Omote, Masaaki and Kato, Katsuhiko and Hiroshi, Yamaguchi and Maki, Okada},
 book = {Peptide Science},
 month = {Feb},
 note = {We developed a positron emission tomography (PET) imaging agent for glutamate transporter (GLT). Direct labeling of glutamic acid enables in vivo observation of amino acid displacement. However, the high permeability of GLT to amino acids makes imaging challenging. This is because direct PET nuclide-labeled amino acids do not bind to transporters. Additionally, excessive modification impedes blood–brain barrier (BBB) permeability. Hence, we report the derivatization of a glutamate molecule and the introduction of a PET nuclide using computational chemistry.},
 pages = {31--34},
 title = {Amino Acid Derivative Design Using Computational Chemistry and Application to PET Tracer},
 year = {2021}
}