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Long-term clinical outcomes after 12-fractionated carbon-ion radiotherapy for localized prostate cancer
https://repo.qst.go.jp/records/84037
https://repo.qst.go.jp/records/8403709bdaf4e-374d-40a8-9f58-68ae1005bdee
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-07-14 | |||||
| タイトル | ||||||
| タイトル | Long-term clinical outcomes after 12-fractionated carbon-ion radiotherapy for localized prostate cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sato, Hiraku
× Sato, Hiraku× Kasuya, Goro× Ishikawa, Hitoshi× Nomoto, Akihiro× Ono, Takashi× Nakajima, Mio× Isozaki, Yuka× Yamamoto, Naoyoshi× Iwai, Yuma× Nemoto, Kenji× Ichikawa, Tomohiko× Tsuji, Hiroshi× Hiraku, Sato× Goro, Kasuya× Hitoshi, Ishikawa× Akihiro, Nomoto× Takashi, Ono× Mio, Nakajima× Yuka, Isozaki× Naoyoshi, Yamamoto× Yuma, Iwai× Kenji, Nemoto× Ichikawa, Tomohiko× Hiroshi, Tsuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There are no clinical reports of long-term follow-up after carbon-ion radiotherapy (CIRT) using a dose of 51.6 Gy (relative biological effectiveness [RBE]) in 12 fractions for localized prostate cancer, or of a comparison of clinical outcomes between passive and scanning beam irradiation. A total of 256 patients with localized prostate cancer who received CIRT at a dose of 51.6 Gy (RBE) in 12 fractions using two different beam delivery techniques (passive [n = 45] and scanning [n = 211]), and who were followed for more than 1 year, were analyzed. The biochemical relapse-free (bRF) rate was defined by the Phoenix definition, and the actuarial toxicity rates were evaluated using the Kaplan-Meier method. Of the 256 patients, 41 (16.0%), 111 (43.4%), and 104 (40.6%) were classified as low, intermediate, and high risk, respectively, after a median follow-up of 7.0 (range 1.1-10.4) years. Androgen deprivation therapy was performed in 212 patients (82.8%). The 5-year bRF rates of the low-, intermediate-, and high-risk patients were 95.1%, 90.9%, and 91.1%, respectively. The 5-year rates of grade 2 late gastrointestinal and genitourinary toxicities in all patients were 0.4% and 6.3%, respectively. No grade ≥3 toxicities were observed. There were no significant differences in the rates of bRF or grade 2 toxicities in patients who received passive irradiation versus scanning irradiation. Our long-term follow-up results showed that a CIRT regimen of 51.6 Gy (RBE) in 12 fractions for localized prostate cancer yielded a good therapeutic outcome and low toxicity rates irrespective of the beam delivery technique. | |||||
| 書誌情報 |
Cancer science 巻 112, 号 9, p. 3598-3606, 発行日 2021-06 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-9032 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34107139 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/cas.15019 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/cas.15019 | |||||
