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  1. 原著論文

Long-term clinical outcomes after 12-fractionated carbon-ion radiotherapy for localized prostate cancer

https://repo.qst.go.jp/records/84037
https://repo.qst.go.jp/records/84037
09bdaf4e-374d-40a8-9f58-68ae1005bdee
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-07-14
タイトル
タイトル Long-term clinical outcomes after 12-fractionated carbon-ion radiotherapy for localized prostate cancer
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Sato, Hiraku

× Sato, Hiraku

WEKO 1014925

Sato, Hiraku

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Kasuya, Goro

× Kasuya, Goro

WEKO 1014926

Kasuya, Goro

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Ishikawa, Hitoshi

× Ishikawa, Hitoshi

WEKO 1014927

Ishikawa, Hitoshi

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Nomoto, Akihiro

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WEKO 1014928

Nomoto, Akihiro

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Ono, Takashi

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WEKO 1014929

Ono, Takashi

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Nakajima, Mio

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WEKO 1014930

Nakajima, Mio

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Isozaki, Yuka

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WEKO 1014931

Isozaki, Yuka

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Yamamoto, Naoyoshi

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WEKO 1014932

Yamamoto, Naoyoshi

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Iwai, Yuma

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WEKO 1014933

Iwai, Yuma

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Nemoto, Kenji

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WEKO 1014934

Nemoto, Kenji

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Ichikawa, Tomohiko

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WEKO 1014935

Ichikawa, Tomohiko

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Tsuji, Hiroshi

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WEKO 1014936

Tsuji, Hiroshi

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Hiraku, Sato

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WEKO 1014937

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Goro, Kasuya

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WEKO 1014938

en Goro, Kasuya

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Hitoshi, Ishikawa

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WEKO 1014939

en Hitoshi, Ishikawa

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Akihiro, Nomoto

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WEKO 1014940

en Akihiro, Nomoto

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Takashi, Ono

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WEKO 1014941

en Takashi, Ono

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Mio, Nakajima

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WEKO 1014942

en Mio, Nakajima

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Yuka, Isozaki

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WEKO 1014943

en Yuka, Isozaki

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Naoyoshi, Yamamoto

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WEKO 1014944

en Naoyoshi, Yamamoto

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Yuma, Iwai

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WEKO 1014945

en Yuma, Iwai

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Kenji, Nemoto

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WEKO 1014946

en Kenji, Nemoto

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Ichikawa, Tomohiko

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WEKO 1014947

en Ichikawa, Tomohiko

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Hiroshi, Tsuji

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WEKO 1014948

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抄録
内容記述タイプ Abstract
内容記述 There are no clinical reports of long-term follow-up after carbon-ion radiotherapy (CIRT) using a dose of 51.6 Gy (relative biological effectiveness [RBE]) in 12 fractions for localized prostate cancer, or of a comparison of clinical outcomes between passive and scanning beam irradiation. A total of 256 patients with localized prostate cancer who received CIRT at a dose of 51.6 Gy (RBE) in 12 fractions using two different beam delivery techniques (passive [n = 45] and scanning [n = 211]), and who were followed for more than 1 year, were analyzed. The biochemical relapse-free (bRF) rate was defined by the Phoenix definition, and the actuarial toxicity rates were evaluated using the Kaplan-Meier method. Of the 256 patients, 41 (16.0%), 111 (43.4%), and 104 (40.6%) were classified as low, intermediate, and high risk, respectively, after a median follow-up of 7.0 (range 1.1-10.4) years. Androgen deprivation therapy was performed in 212 patients (82.8%). The 5-year bRF rates of the low-, intermediate-, and high-risk patients were 95.1%, 90.9%, and 91.1%, respectively. The 5-year rates of grade 2 late gastrointestinal and genitourinary toxicities in all patients were 0.4% and 6.3%, respectively. No grade ≥3 toxicities were observed. There were no significant differences in the rates of bRF or grade 2 toxicities in patients who received passive irradiation versus scanning irradiation. Our long-term follow-up results showed that a CIRT regimen of 51.6 Gy (RBE) in 12 fractions for localized prostate cancer yielded a good therapeutic outcome and low toxicity rates irrespective of the beam delivery technique.
書誌情報 Cancer science

巻 112, 号 9, p. 3598-3606, 発行日 2021-06
出版者
出版者 Wiley
ISSN
収録物識別子タイプ ISSN
収録物識別子 1347-9032
PubMed番号
識別子タイプ PMID
関連識別子 34107139
DOI
識別子タイプ DOI
関連識別子 10.1111/cas.15019
関連サイト
識別子タイプ URI
関連識別子 https://onlinelibrary.wiley.com/doi/full/10.1111/cas.15019
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