WEKO3
アイテム
Free energy profile of H2A-H2B dimer displacement from nucleosome
https://repo.qst.go.jp/records/83722
https://repo.qst.go.jp/records/837222cf54621-58a4-46d5-9f3c-aad09c2f7032
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-11-04 | |||||
タイトル | ||||||
タイトル | Free energy profile of H2A-H2B dimer displacement from nucleosome | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hisashi, Ishida
× Hisashi, Ishida× Hidetoshi, Kono× Hisashi, Ishida× Hidetoshi, Kono |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Nucleosome reconstitution plays an important role in many cellular functions. As the initial step of the H2A-H2B dimer eviction, dimer displacement, which is accompanied by disruption of many of the interactions within the nucleosome, should occur. To understand how H2A/H2B dimer displacement occurs, we carried out all-atom molecular dynamics simulations of wrapped and unwrapped nucleosomes. The free energies for the dimer displacement from these nucleosomes were estimated to be similar, about 30 kcal/mol, but the pathways for the dimer displacement were different. We found that conformational disrupt at the interface between the docking domain of H2A and the adjacent regions of H3 αN-helix, H3 αC-helix and H4 C-terminal significantly contributed to the free energy. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第59回日本生物物理学会年会 | |||||
発表年月日 | ||||||
日付 | 2021-11-25 | |||||
日付タイプ | Issued |