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Free energy profile of H2A-H2B dimer displacement from nucleosome
https://repo.qst.go.jp/records/83722
https://repo.qst.go.jp/records/837222cf54621-58a4-46d5-9f3c-aad09c2f7032
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-04 | |||||
| タイトル | ||||||
| タイトル | Free energy profile of H2A-H2B dimer displacement from nucleosome | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hisashi, Ishida
× Hisashi, Ishida× Hidetoshi, Kono× Hisashi, Ishida× Hidetoshi, Kono |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nucleosome reconstitution plays an important role in many cellular functions. As the initial step of the H2A-H2B dimer eviction, dimer displacement, which is accompanied by disruption of many of the interactions within the nucleosome, should occur. To understand how H2A/H2B dimer displacement occurs, we carried out all-atom molecular dynamics simulations of wrapped and unwrapped nucleosomes. The free energies for the dimer displacement from these nucleosomes were estimated to be similar, about 30 kcal/mol, but the pathways for the dimer displacement were different. We found that conformational disrupt at the interface between the docking domain of H2A and the adjacent regions of H3 αN-helix, H3 αC-helix and H4 C-terminal significantly contributed to the free energy. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第59回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-11-25 | |||||
| 日付タイプ | Issued | |||||
