@misc{oai:repo.qst.go.jp:00083722,
 author = {Hisashi, Ishida and Hidetoshi, Kono and Hisashi, Ishida and Hidetoshi, Kono},
 month = {Nov},
 note = {Nucleosome reconstitution plays an important role in many cellular functions.  As the initial step of the H2A-H2B dimer eviction, dimer displacement, which is accompanied by disruption of many of the interactions within the nucleosome, should occur.  To understand how H2A/H2B dimer displacement occurs, we carried out all-atom molecular dynamics simulations of wrapped and unwrapped nucleosomes.  The free energies for the dimer displacement from these nucleosomes were estimated to be similar, about 30 kcal/mol, but the pathways for the dimer displacement were different.  We found that conformational disrupt at the interface between the docking domain of H2A and the adjacent regions of H3 αN-helix, H3 αC-helix and H4 C-terminal significantly contributed to the free energy., 第59回日本生物物理学会年会},
 title = {Free energy profile of H2A-H2B dimer displacement from nucleosome},
 year = {2021}
}