{"created":"2023-05-15T15:01:43.334761+00:00","id":83722,"links":{},"metadata":{"_buckets":{"deposit":"00677805-d652-47db-ac9b-08d78327d0c7"},"_deposit":{"created_by":1,"id":"83722","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83722"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083722","sets":["10:29"]},"author_link":["1009257","1009255","1009256","1009254"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-11-25","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nucleosome reconstitution plays an important role in many cellular functions.  As the initial step of the H2A-H2B dimer eviction, dimer displacement, which is accompanied by disruption of many of the interactions within the nucleosome, should occur.  To understand how H2A/H2B dimer displacement occurs, we carried out all-atom molecular dynamics simulations of wrapped and unwrapped nucleosomes.  The free energies for the dimer displacement from these nucleosomes were estimated to be similar, about 30 kcal/mol, but the pathways for the dimer displacement were different.  We found that conformational disrupt at the interface between the docking domain of H2A and the adjacent regions of H3 αN-helix, H3 αC-helix and H4 C-terminal significantly contributed to the free energy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第59回日本生物物理学会年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hisashi, Ishida"}],"nameIdentifiers":[{"nameIdentifier":"1009254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hidetoshi, Kono"}],"nameIdentifiers":[{"nameIdentifier":"1009255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Ishida","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hidetoshi, Kono","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009257","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Free energy profile of H2A-H2B dimer displacement from nucleosome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Free energy profile of H2A-H2B dimer displacement from nucleosome"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-04"},"publish_date":"2021-11-04","publish_status":"0","recid":"83722","relation_version_is_last":true,"title":["Free energy profile of H2A-H2B dimer displacement from nucleosome"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:08:38.868582+00:00"}