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免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐA novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death
https://repo.qst.go.jp/records/83529
https://repo.qst.go.jp/records/8352920980da9-da81-4d01-a822-958f43409ae2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-21 | |||||
| タイトル | ||||||
| タイトル | 免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐA novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tanimoto, Taiga
× Tanimoto, Taiga× Akinori, Morita× Yuichi, Nishiyama× Murata, Takatsugu× Sakai, Anjyu× Kanai, Akinori× Higashi, Yuichi× Kunii, Taisei× Takuma, Sakai× Sadatomi, Ryou× Bing, Wang× Takashi, Shimokawa× Nakata, Kenya× Takemura, Naoki× Saitoh, Tatsuya× Toshiya, Inaba× Shiina, Isamu× Akinori, Morita× Yuichi, Nishiyama× Takuma, Sakai× Bing, Wang× Takashi, Shimokawa× Toshiya, Inaba |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have found that novel radioprotective agents, which are tentatively designated as compounds A and STA because a patent application is being considered, have remarkable protective effect against intestinal death in mouse sub-total body irradiation (SBI) experiments. In this study, we evaluated the radioprotective activity of a more effective compound, STA, in which one of the core structures of compound A is substituted to an ethyl group in order to enhance blood persistence and enhance the radioprotective effect. As a result, a potent radioprotective effect against radiation enteritis was observed in C57BL/6N mice treated with 26 Gy-SBI. The optimal dose of STA for the radiation protection was 10 mg/kg, while the maximum tolerated dose (MTD) is 40 mg/kg or less in a MTD study. Next, mRNA-Seq analysis of small intestinal mucosa was performed to identify genes related to radiation protection of acute gastrointestinal syndrome by STA. As a result, we found no significant change in any p53 target genes investigated and various changes of autoimmune or inflammatory response-related genes. Especially, many of the Toll-like receptor genes were down-regulated. In addition, SBI experiments were performed on Casp1/4(11)-deficient mice, which show a lack of producing inflammatory cytokines. STA did not show any radioprotective effect on the mice, indicating that the radioprotective effect of STA is dependent on Caspase-1/Caspase-4(11). Currently, we are confirming the reproducibility of the gene expression changes by STA using qPCR, and plan to report the results obtained. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第64回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-09-22 | |||||
| 日付タイプ | Issued | |||||
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Tanimoto, Taiga, Akinori, Morita, Yuichi, Nishiyama, Murata, Takatsugu, Sakai, Anjyu, Kanai, Akinori, Higashi, Yuichi, Kunii, Taisei, Takuma, Sakai, Sadatomi, Ryou, Bing, Wang, Takashi, Shimokawa, Nakata, Kenya, Takemura, Naoki, Saitoh, Tatsuya, Toshiya, Inaba, Shiina, Isamu, Akinori, Morita, Yuichi, Nishiyama, Takuma, Sakai, Bing, Wang, Takashi, Shimokawa, Toshiya, Inaba, 2021, 免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐA novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death.
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