{"created":"2023-05-15T15:01:34.662378+00:00","id":83529,"links":{},"metadata":{"_buckets":{"deposit":"f40cfa54-014b-467c-b0f6-f0ed430af9b2"},"_deposit":{"created_by":1,"id":"83529","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83529"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083529","sets":["10:28"]},"author_link":["1006476","1006482","1006490","1006492","1006493","1006491","1006497","1006484","1006495","1006479","1006477","1006480","1006481","1006485","1006483","1006488","1006486","1006494","1006478","1006475","1006489","1006496","1006487"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-09-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have found that novel radioprotective agents, which are tentatively designated as compounds A and STA because a patent application is being considered, have remarkable protective effect against intestinal death in mouse sub-total body irradiation (SBI) experiments. In this study, we evaluated the radioprotective activity of a more effective compound, STA, in which one of the core structures of compound A is substituted to an ethyl group in order to enhance blood persistence and enhance the radioprotective effect. As a result, a potent radioprotective effect against radiation enteritis was observed in C57BL/6N mice treated with 26 Gy-SBI. The optimal dose of STA for the radiation protection was 10 mg/kg, while the maximum tolerated dose (MTD) is 40 mg/kg or less in a MTD study. Next, mRNA-Seq analysis of small intestinal mucosa was performed to identify genes related to radiation protection of acute gastrointestinal syndrome by STA. As a result, we found no significant change in any p53 target genes investigated and various changes of autoimmune or inflammatory response-related genes. Especially, many of the Toll-like receptor genes were down-regulated. In addition, SBI experiments were performed on Casp1/4(11)-deficient mice, which show a lack of producing inflammatory cytokines. STA did not show any radioprotective effect on the mice, indicating that the radioprotective effect of STA is dependent on Caspase-1/Caspase-4(11). Currently, we are confirming the reproducibility of the gene expression changes by STA using qPCR, and plan to report the results obtained.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第64回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanimoto, Taiga"}],"nameIdentifiers":[{"nameIdentifier":"1006475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akinori, Morita"}],"nameIdentifiers":[{"nameIdentifier":"1006476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuichi, Nishiyama"}],"nameIdentifiers":[{"nameIdentifier":"1006477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Takatsugu"}],"nameIdentifiers":[{"nameIdentifier":"1006478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Anjyu"}],"nameIdentifiers":[{"nameIdentifier":"1006479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanai, Akinori"}],"nameIdentifiers":[{"nameIdentifier":"1006480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"1006481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kunii, Taisei"}],"nameIdentifiers":[{"nameIdentifier":"1006482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuma, Sakai"}],"nameIdentifiers":[{"nameIdentifier":"1006483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sadatomi, Ryou"}],"nameIdentifiers":[{"nameIdentifier":"1006484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"1006485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takashi, Shimokawa"}],"nameIdentifiers":[{"nameIdentifier":"1006486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakata, Kenya"}],"nameIdentifiers":[{"nameIdentifier":"1006487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takemura, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"1006488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saitoh, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"1006489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiya, Inaba"}],"nameIdentifiers":[{"nameIdentifier":"1006490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiina, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"1006491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akinori, Morita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuichi, Nishiyama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuma, Sakai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takashi, Shimokawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiya, Inaba","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006497","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐA novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐA novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-21"},"publish_date":"2021-06-21","publish_status":"0","recid":"83529","relation_version_is_last":true,"title":["免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐA novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:20:14.135589+00:00"}