@misc{oai:repo.qst.go.jp:00083529,
 author = {Tanimoto, Taiga and Akinori, Morita and Yuichi, Nishiyama and Murata, Takatsugu and Sakai, Anjyu and Kanai, Akinori and Higashi, Yuichi and Kunii, Taisei and Takuma, Sakai and Sadatomi, Ryou and Bing, Wang and Takashi, Shimokawa and Nakata, Kenya and Takemura, Naoki and Saitoh, Tatsuya and Toshiya, Inaba and Shiina, Isamu and Akinori, Morita and Yuichi, Nishiyama and Takuma, Sakai and Bing, Wang and Takashi, Shimokawa and Toshiya, Inaba},
 month = {Sep},
 note = {We have found that novel radioprotective agents, which are tentatively designated as compounds A and STA because a patent application is being considered, have remarkable protective effect against intestinal death in mouse sub-total body irradiation (SBI) experiments. In this study, we evaluated the radioprotective activity of a more effective compound, STA, in which one of the core structures of compound A is substituted to an ethyl group in order to enhance blood persistence and enhance the radioprotective effect. As a result, a potent radioprotective effect against radiation enteritis was observed in C57BL/6N mice treated with 26 Gy-SBI. The optimal dose of STA for the radiation protection was 10 mg/kg, while the maximum tolerated dose (MTD) is 40 mg/kg or less in a MTD study. Next, mRNA-Seq analysis of small intestinal mucosa was performed to identify genes related to radiation protection of acute gastrointestinal syndrome by STA. As a result, we found no significant change in any p53 target genes investigated and various changes of autoimmune or inflammatory response-related genes. Especially, many of the Toll-like receptor genes were down-regulated. In addition, SBI experiments were performed on Casp1/4(11)-deficient mice, which show a lack of producing inflammatory cytokines. STA did not show any radioprotective effect on the mice, indicating that the radioprotective effect of STA is dependent on Caspase-1/Caspase-4(11). Currently, we are confirming the reproducibility of the gene expression changes by STA using qPCR, and plan to report the results obtained., 日本放射線影響学会第64回大会},
 title = {免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐA novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death},
 year = {2021}
}