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  1. 原著論文

The Emerging Potential of Multi-Ion Radiotherapy

https://repo.qst.go.jp/records/82336
https://repo.qst.go.jp/records/82336
2fa5cd3e-8596-426f-82c4-65723e3b9d89
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-03-22
タイトル
タイトル The Emerging Potential of Multi-Ion Radiotherapy
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Ebner, Daniel

× Ebner, Daniel

WEKO 1015774

Ebner, Daniel

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J. Frank, Steven

× J. Frank, Steven

WEKO 1015775

J. Frank, Steven

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Taku, Inaniwa

× Taku, Inaniwa

WEKO 1015776

Taku, Inaniwa

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Shigeru, Yamada

× Shigeru, Yamada

WEKO 1015777

Shigeru, Yamada

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Toshiyuki, Shirai

× Toshiyuki, Shirai

WEKO 1015778

Toshiyuki, Shirai

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Ebner, Daniel

× Ebner, Daniel

WEKO 1015779

en Ebner, Daniel

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Taku, Inaniwa

× Taku, Inaniwa

WEKO 1015780

en Taku, Inaniwa

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Shigeru, Yamada

× Shigeru, Yamada

WEKO 1015781

en Shigeru, Yamada

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Toshiyuki, Shirai

× Toshiyuki, Shirai

WEKO 1015782

en Toshiyuki, Shirai

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抄録
内容記述タイプ Abstract
内容記述 Research into high linear energy transfer (LET) radiotherapy now spans over half a century, beginning with helium and deuteron treatment in 1952 and today ranging from fast neutrons to carbon-ions. Owing to pioneering work initially in the United States and thereafter in Germany and Japan, increasing focus is on the carbon-ion beam: 12 centers are in operation, with five under construction and three in planning. While the carbon-ion beam has demonstrated unique and promising suitability in laboratory and clinical trials toward the hypofractionated treatment of hypoxic and/or radioresistant cancer, substantial developmental potential remains. Perhaps most notable is the ability to paint LET in a tumor, theoretically better focusing damage delivery within the most resistant areas. However, the technique may be limited in practice by the physical properties of the beams themselves. A heavy-ion synchrotron may provide irradiation with multiple heavy-ions: carbon, helium, and oxygen are prime candidates. Each ion varies in LET distribution, and so a methodology combining the use of multiple ions into a uniform LET distribution within a tumor may allow for even greater treatment potential in radioresistant cancer.
書誌情報 Frontiers in oncology

巻 11, p. 624786, 発行日 2021-02
出版者
出版者 Frontiers in oncology
ISSN
収録物識別子タイプ ISSN
収録物識別子 2234-943X
PubMed番号
識別子タイプ PMID
関連識別子 33692957
DOI
識別子タイプ DOI
関連識別子 10.3389/fonc.2021.624786
関連サイト
識別子タイプ URI
関連識別子 https://www.frontiersin.org/articles/10.3389/fonc.2021.624786/full
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