{"created":"2023-05-15T15:00:41.510558+00:00","id":82336,"links":{},"metadata":{"_buckets":{"deposit":"a5689c4e-0b66-415e-b51a-b24c46fc9ec6"},"_deposit":{"created_by":1,"id":"82336","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82336"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082336","sets":["1"]},"author_link":["1015780","1015778","1015779","1015776","1015774","1015782","1015777","1015775","1015781"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"624786","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Frontiers in oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Research into high linear energy transfer (LET) radiotherapy now spans over half a century, beginning with helium and deuteron treatment in 1952 and today ranging from fast neutrons to carbon-ions. Owing to pioneering work initially in the United States and thereafter in Germany and Japan, increasing focus is on the carbon-ion beam: 12 centers are in operation, with five under construction and three in planning. While the carbon-ion beam has demonstrated unique and promising suitability in laboratory and clinical trials toward the hypofractionated treatment of hypoxic and/or radioresistant cancer, substantial developmental potential remains. Perhaps most notable is the ability to paint LET in a tumor, theoretically better focusing damage delivery within the most resistant areas. However, the technique may be limited in practice by the physical properties of the beams themselves. A heavy-ion synchrotron may provide irradiation with multiple heavy-ions: carbon, helium, and oxygen are prime candidates. Each ion varies in LET distribution, and so a methodology combining the use of multiple ions into a uniform LET distribution within a tumor may allow for even greater treatment potential in radioresistant cancer. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers in oncology"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33692957","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3389/fonc.2021.624786","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.frontiersin.org/articles/10.3389/fonc.2021.624786/full","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2234-943X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ebner, Daniel"}],"nameIdentifiers":[{"nameIdentifier":"1015774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J. Frank, Steven"}],"nameIdentifiers":[{"nameIdentifier":"1015775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taku, Inaniwa"}],"nameIdentifiers":[{"nameIdentifier":"1015776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeru, Yamada"}],"nameIdentifiers":[{"nameIdentifier":"1015777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiyuki, Shirai"}],"nameIdentifiers":[{"nameIdentifier":"1015778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ebner, Daniel","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1015779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taku, Inaniwa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1015780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeru, Yamada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1015781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiyuki, Shirai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1015782","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Emerging Potential of Multi-Ion Radiotherapy ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Emerging Potential of Multi-Ion Radiotherapy "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-22"},"publish_date":"2021-03-22","publish_status":"0","recid":"82336","relation_version_is_last":true,"title":["The Emerging Potential of Multi-Ion Radiotherapy "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:42:21.387797+00:00"}