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COX-2を指標とした放射線誘発バイスタンダー細胞応答に関する研究Analysis of radiation induced bystander response by COX-2 induction in A549 human lung carcinoma cells（18SJ05）
https://repo.qst.go.jp/records/82049
https://repo.qst.go.jp/records/82049ae05b658-4416-430e-a283-3ed9dae3894c
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-03 | |||||
| タイトル | ||||||
| タイトル | COX-2を指標とした放射線誘発バイスタンダー細胞応答に関する研究Analysis of radiation induced bystander response by COX-2 induction in A549 human lung carcinoma cells（18SJ05） | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
小林, 亜利紗
× 小林, 亜利紗× 大澤, 大輔× Dukaew, Nahathai× Autosavapromporn, Narongchai× Ahbrizal Farizal Tengku Ahmad, Tengku× 小西, 輝昭× Alisa, Kobayashi× Daisuke, Ohsawa× Teruaki, Konishi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is known that radiation-induced bystander effect (RIBE) regulates radio-resistance in vivo and in vitro [1, 2]. In our previous studies with SPICE, targeted radiation of cancer cells induces DNA double-strand breaks in non-irradiated normal cells surrounding it. On the other hand, DNA double strand break repair of irradiated cancer cells were enhanced by the non-irradiated normal cells [3, 4]. These results suggest that the radio-sensitivity of irradiated cancer cells and non-irradiated normal cells is modified by bystander responses. COX-2 (cycrooxygenase-2) is well known as a bystander mediator [5]. In addition, COX-2 also plays a role in enhancing the radio-resistance of cancer cells [6]. In previous research, we reported that COX-2 expression is increased in 24 hours post irradiate A549 cells < 0.01% of total cells using SPICE microbeam. Therefore, in this fiscal year, we try to evaluate the relationship between COX-2 expression and radiation resistance in bystander cells using SPICE microbeam. |
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| 書誌情報 |
令和元年度 共用施設(PASTA&SPICE、NASBEE、X/γ線照射装置)成果報告書 p. 23-24, 発行日 2021-03 |
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