@article{oai:repo.qst.go.jp:00082049,
 author = {小林, 亜利紗 and 大澤, 大輔 and Dukaew, Nahathai and Autosavapromporn, Narongchai and Ahbrizal Farizal Tengku Ahmad, Tengku and 小西, 輝昭 and Alisa, Kobayashi and Daisuke, Ohsawa and Teruaki, Konishi},
 journal = {令和元年度 共用施設(PASTA&SPICE、NASBEE、X/γ線照射装置)成果報告書},
 month = {Mar},
 note = {It is known that radiation-induced bystander effect (RIBE) regulates radio-resistance in vivo and in vitro [1, 2]. In our previous studies with SPICE, targeted radiation of cancer cells induces DNA double-strand breaks in non-irradiated normal cells surrounding it. On the other hand, DNA double strand break repair of irradiated cancer cells were enhanced by the non-irradiated normal cells [3, 4]. These results suggest that the radio-sensitivity of irradiated cancer cells and non-irradiated normal cells is modified by bystander responses.
COX-2 (cycrooxygenase-2) is well known as a bystander mediator [5]. In addition, COX-2 also plays a role in enhancing the radio-resistance of cancer cells [6]. In previous research, we reported that COX-2 expression is increased in 24 hours post irradiate A549 cells < 0.01% of total cells using SPICE microbeam. 
Therefore, in this fiscal year, we try to evaluate the relationship between COX-2 expression and radiation resistance in bystander cells using SPICE microbeam.},
 pages = {23--24},
 title = {COX-2を指標とした放射線誘発バイスタンダー細胞応答に関する研究Analysis of radiation induced bystander response by COX-2 induction in A549 human lung carcinoma cells（18SJ05）},
 year = {2021}
}