{"created":"2023-05-15T15:00:27.513024+00:00","id":82049,"links":{},"metadata":{"_buckets":{"deposit":"a88ebf88-3531-428c-b5e4-817f75f2fb93"},"_deposit":{"created_by":1,"id":"82049","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82049"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082049","sets":["7"]},"author_link":["931159","931158","931162","931155","931154","931156","931160","931157","931161"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"24","bibliographicPageStart":"23","bibliographic_titles":[{"bibliographic_title":"令和元年度 共用施設(PASTA&SPICE、NASBEE、X/γ線照射装置)成果報告書"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is known that radiation-induced bystander effect (RIBE) regulates radio-resistance in vivo and in vitro [1, 2]. In our previous studies with SPICE, targeted radiation of cancer cells induces DNA double-strand breaks in non-irradiated normal cells surrounding it. On the other hand, DNA double strand break repair of irradiated cancer cells were enhanced by the non-irradiated normal cells [3, 4]. These results suggest that the radio-sensitivity of irradiated cancer cells and non-irradiated normal cells is modified by bystander responses.\nCOX-2 (cycrooxygenase-2) is well known as a bystander mediator [5]. In addition, COX-2 also plays a role in enhancing the radio-resistance of cancer cells [6]. In previous research, we reported that COX-2 expression is increased in 24 hours post irradiate A549 cells < 0.01% of total cells using SPICE microbeam. \nTherefore, in this fiscal year, we try to evaluate the relationship between COX-2 expression and radiation resistance in bystander cells using SPICE microbeam.\n","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 亜利紗"}],"nameIdentifiers":[{"nameIdentifier":"931154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大澤, 大輔"}],"nameIdentifiers":[{"nameIdentifier":"931155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dukaew, Nahathai"}],"nameIdentifiers":[{"nameIdentifier":"931156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Autosavapromporn, Narongchai"}],"nameIdentifiers":[{"nameIdentifier":"931157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ahbrizal Farizal Tengku Ahmad, Tengku"}],"nameIdentifiers":[{"nameIdentifier":"931158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西, 輝昭"}],"nameIdentifiers":[{"nameIdentifier":"931159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Alisa, Kobayashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"931160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daisuke, Ohsawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"931161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Teruaki, Konishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"931162","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"COX-2を指標とした放射線誘発バイスタンダー細胞応答に関する研究Analysis of radiation induced bystander response by COX-2 induction in A549 human lung carcinoma cells（18SJ05）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"COX-2を指標とした放射線誘発バイスタンダー細胞応答に関する研究Analysis of radiation induced bystander response by COX-2 induction in A549 human lung carcinoma cells（18SJ05）"}]},"item_type_id":"10004","owner":"1","path":["7"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-03"},"publish_date":"2021-03-03","publish_status":"0","recid":"82049","relation_version_is_last":true,"title":["COX-2を指標とした放射線誘発バイスタンダー細胞応答に関する研究Analysis of radiation induced bystander response by COX-2 induction in A549 human lung carcinoma cells（18SJ05）"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:38:20.996268+00:00"}