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Impact of short-term high-fat feeding on lipid droplet content in mouse oocytes
https://repo.qst.go.jp/records/81933
https://repo.qst.go.jp/records/8193322b10531-55ab-4785-a7b4-c910ce09d7d7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-27 | |||||
| タイトル | ||||||
| タイトル | Impact of short-term high-fat feeding on lipid droplet content in mouse oocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Aizawa, Ryutaro
× Aizawa, Ryutaro× Ibayashi, Megumi× Hatakeyama, Tomomi× Tatsumi, Takayuki× Tsukamoto, Satoshi× Ryutaro, Aizawa× Megumi, Ibayashi× Hatakeyama, Tomomi× Takayuki, Tatsumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mature mammalian oocytes contain lipid droplets (LDs), which are neutral lipid storage organelles critically important for energy metabolism. In mice, maternal obesity, induced by long-term (> 3 months) high-fat feeding, contributes to the accumulation of LDs in mature oocytes. However, few studies have investigated the influence of short-term high-fat feeding on LD content. In this study, we demonstrated that 3 weeks of high-fat feeding is sufficient to increase LD content and intracellular triacylglycerol levels. Using a two-step centrifugation technique to release LDs into the perivitelline space, we found that short-term high-fat feeding increased the level of LDs in MII oocytes and that 3 days of high-fat feeding were sufficient to increase efficiency of LD release. Collectively, our study suggests that short-term high fat feeding can have a higher impact on lipid metabolism during oocyte maturation. | |||||
| 書誌情報 |
The Journal of reproduction and development 巻 67, 号 1, p. 73-77, 発行日 2021-02 |
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| 出版者 | ||||||
| 出版者 | 日本繁殖生物学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0916-8818 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33071247 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1262/jrd.2020-094 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_2020-094/_article/-char/ja/ | |||||
