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Initial Imaging Results of a Mouse Brain PET Prototype with a Staggered 3-Layer DOI Detector

https://repo.qst.go.jp/records/80864
https://repo.qst.go.jp/records/80864
e9f3961a-937c-467f-b511-6e8f2945177a
Item type 会議発表用資料 / Presentation(1)
公開日 2020-11-02
タイトル
タイトル Initial Imaging Results of a Mouse Brain PET Prototype with a Staggered 3-Layer DOI Detector
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Kang, Hangyu

× Kang, Hangyu

WEKO 916867

Kang, Hangyu

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Kang, Hangyu

× Kang, Hangyu

WEKO 916868

en Kang, Hangyu

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抄録
内容記述タイプ Abstract
内容記述 The spatial resolution of a small animal positron emission tomography (PET) scanner deteriorates significantly at the field of view (FOV) periphery due to the parallax error. In a previous study, we proposed a staggered 3-layer depth-of-interaction (DOI) detector with a 1 mm crystal pitch to achieve high resolution while minimizing the parallax error. In this study, we present the initial results of a prototype small animal PET scanner using a staggered 3-layer DOI detector for submillimeter mouse brain imaging. The prototype small animal PET scanner had a 52 mm inner diameter and 11 mm axial coverage. The LYSO crystal array had the pixel pitch of 1 mm and total thickness of 15 mm. The PET scanner consisted of 16 DOI detectors which of each had a 3-layer staggered LYSO crystal array. The LYSO crystal array was optically coupled to a 4×4 SiPM (Hamamatsu, S14161-3050HS-04, Japan) array with a pixel pitch of 3.2 mm. The SiPM anode signals were multiplexed using a resistive network and then digitized by the Hamamatsu DAQ with an integration time of 250 ns. The coincidence data were generated by using coincidence process software with a coincidence window of 20 ns. The measured spatial resolutions at the center and 15 mm radial offset were 0.67 mm, and 1.56 mm for filtered-back-projection (FBP), and 0.50 mm, and 1.16 mm for ordered-subset-expectation-maximization (OSEM), respectively. The peak absolute sensitivity was 0.76% with an energy window of 400-600 keV. In conclusion, we developed a high-resolution and high-sensitivity mouse brain dedicated PET scanner with 3-layer DOI detectors. In the near future, we will perform a mouse brain imaging study using the prototype PET scanner.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 2020 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference
発表年月日
日付 2020-11-05
日付タイプ Issued
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