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Initial Imaging Results of a Mouse Brain PET Prototype with a Staggered 3-Layer DOI Detector
https://repo.qst.go.jp/records/80864
https://repo.qst.go.jp/records/80864e9f3961a-937c-467f-b511-6e8f2945177a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-02 | |||||
| タイトル | ||||||
| タイトル | Initial Imaging Results of a Mouse Brain PET Prototype with a Staggered 3-Layer DOI Detector | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kang, Hangyu
× Kang, Hangyu× Kang, Hangyu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The spatial resolution of a small animal positron emission tomography (PET) scanner deteriorates significantly at the field of view (FOV) periphery due to the parallax error. In a previous study, we proposed a staggered 3-layer depth-of-interaction (DOI) detector with a 1 mm crystal pitch to achieve high resolution while minimizing the parallax error. In this study, we present the initial results of a prototype small animal PET scanner using a staggered 3-layer DOI detector for submillimeter mouse brain imaging. The prototype small animal PET scanner had a 52 mm inner diameter and 11 mm axial coverage. The LYSO crystal array had the pixel pitch of 1 mm and total thickness of 15 mm. The PET scanner consisted of 16 DOI detectors which of each had a 3-layer staggered LYSO crystal array. The LYSO crystal array was optically coupled to a 4×4 SiPM (Hamamatsu, S14161-3050HS-04, Japan) array with a pixel pitch of 3.2 mm. The SiPM anode signals were multiplexed using a resistive network and then digitized by the Hamamatsu DAQ with an integration time of 250 ns. The coincidence data were generated by using coincidence process software with a coincidence window of 20 ns. The measured spatial resolutions at the center and 15 mm radial offset were 0.67 mm, and 1.56 mm for filtered-back-projection (FBP), and 0.50 mm, and 1.16 mm for ordered-subset-expectation-maximization (OSEM), respectively. The peak absolute sensitivity was 0.76% with an energy window of 400-600 keV. In conclusion, we developed a high-resolution and high-sensitivity mouse brain dedicated PET scanner with 3-layer DOI detectors. In the near future, we will perform a mouse brain imaging study using the prototype PET scanner. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2020 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2020-11-05 | |||||
| 日付タイプ | Issued | |||||
