@misc{oai:repo.qst.go.jp:00080864,
 author = {Kang, Hangyu and Kang, Hangyu},
 month = {Nov},
 note = {The spatial resolution of a small animal positron emission tomography (PET) scanner deteriorates significantly at the field of view (FOV) periphery due to the parallax error. In a previous study, we proposed a staggered 3-layer depth-of-interaction (DOI) detector with a 1 mm crystal pitch to achieve high resolution while minimizing the parallax error. In this study, we present the initial results of a prototype small animal PET scanner using a staggered 3-layer DOI detector for submillimeter mouse brain imaging. The prototype small animal PET scanner had a 52 mm inner diameter and 11 mm axial coverage. The LYSO crystal array had the pixel pitch of 1 mm and total thickness of 15 mm. The PET scanner consisted of 16 DOI detectors which of each had a 3-layer staggered LYSO crystal array. The LYSO crystal array was optically coupled to a 4×4 SiPM (Hamamatsu, S14161-3050HS-04, Japan) array with a pixel pitch of 3.2 mm. The SiPM anode signals were multiplexed using a resistive network and then digitized by the Hamamatsu DAQ with an integration time of 250 ns. The coincidence data were generated by using coincidence process software with a coincidence window of 20 ns. The measured spatial resolutions at the center and 15 mm radial offset were 0.67 mm, and 1.56 mm for filtered-back-projection (FBP), and 0.50 mm, and 1.16 mm for ordered-subset-expectation-maximization (OSEM), respectively. The peak absolute sensitivity was 0.76% with an energy window of 400-600 keV. In conclusion, we developed a high-resolution and high-sensitivity mouse brain dedicated PET scanner with 3-layer DOI detectors. In the near future, we will perform a mouse brain imaging study using the prototype PET scanner., 2020 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference},
 title = {Initial Imaging Results of a Mouse Brain PET Prototype with a Staggered 3-Layer DOI Detector},
 year = {2020}
}