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Ca2+ waves as stress signals in X-irradiated cells
https://repo.qst.go.jp/records/80774
https://repo.qst.go.jp/records/807743fbde6d4-4505-4622-9dc3-dcfdc65b0b43
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-13 | |||||
| タイトル | ||||||
| タイトル | Ca2+ waves as stress signals in X-irradiated cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Ami
× Suzuki, Ami× Yokoya, Akinari× Suzuki, Ami× Yokoya, Akinari |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To react to stimuli from a circumstance, such as ionizing irradiation, living systems use various wave-like signals as communication tools. In this study, we focus on fluctuation of the Ca2+ concentration as a second messenger within cells exposed to an ionizing radiation. Normally, Ca2+ ions are stored in endoplasmic reticulum (ER) or mitochondria. In response to the environmental change, ER promptly discharges the ions resulting in a temporal periodic change of Ca2+ concentration in the cell. This oscillation is called Ca2+ wave and its propagation within the cells has been suggested to control various physiological functions. For example, glial cells in a neural system mutually communicate together by the electronical or the chemical waves. Our object is to clarify whether the Ca2+ waves arise when cells are exposed to an ionizing radiation to regulate their stress responses. We tried to establish an experimental method to visualize the Ca2+ concentration in the various mammalian cells. The cells were treated with a Ca2+ specific chemical fluorescent probe, Fluo 4. Time lapse observations were performed for the cells using a fluorescent microscope. In addition to background fluorescence, a progressive increase or a temporal burst-like Ca2+ concentration-change was seen in some of the cells exposed to X-rays. In conclusion, waves of chemical concentration change of specific signal molecules such as Ca2+ ions might play an important role in communications between not only cells but also organelles in response to radiation stress. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第63回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-10-15 | |||||
| 日付タイプ | Issued | |||||
