@misc{oai:repo.qst.go.jp:00080774,
 author = {Suzuki, Ami and Yokoya, Akinari and Suzuki, Ami and Yokoya, Akinari},
 month = {Oct},
 note = {To react to stimuli from a circumstance, such as ionizing irradiation, living systems use various wave-like signals as communication tools. In this study, we focus on fluctuation of the Ca2+ concentration as a second messenger within cells exposed to an ionizing radiation. Normally, Ca2+ ions are stored in endoplasmic reticulum (ER) or mitochondria. In response to the environmental change, ER promptly discharges the ions resulting in a temporal periodic change of Ca2+ concentration in the cell. This oscillation is called Ca2+ wave and its propagation within the cells has been suggested to control various physiological functions. For example, glial cells in a neural system mutually communicate together by the electronical or the chemical waves. Our object is to clarify whether the Ca2+ waves arise when cells are exposed to an ionizing radiation to regulate their stress responses. We tried to establish an experimental method to visualize the Ca2+ concentration in the various mammalian cells. The cells were treated with a Ca2+ specific chemical fluorescent probe, Fluo 4. Time lapse observations were performed for the cells using a fluorescent microscope. In addition to background fluorescence, a progressive increase or a temporal burst-like Ca2+ concentration-change was seen in some of the cells exposed to X-rays. In conclusion, waves of chemical concentration change of specific signal molecules such as Ca2+ ions might play an important role in communications between not only cells but also organelles in response to radiation stress., 日本放射線影響学会第63回大会},
 title = {Ca2+ waves as stress signals in X-irradiated cells},
 year = {2020}
}