{"created":"2023-05-15T14:59:31.871917+00:00","id":80774,"links":{},"metadata":{"_buckets":{"deposit":"e5a28dc6-44c8-4fde-95a7-2ae7f52b5325"},"_deposit":{"created_by":1,"id":"80774","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80774"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080774","sets":["10:28"]},"author_link":["894833","894836","894835","894834"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-10-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To react to stimuli from a circumstance, such as ionizing irradiation, living systems use various wave-like signals as communication tools. In this study, we focus on fluctuation of the Ca2+ concentration as a second messenger within cells exposed to an ionizing radiation. Normally, Ca2+ ions are stored in endoplasmic reticulum (ER) or mitochondria. In response to the environmental change, ER promptly discharges the ions resulting in a temporal periodic change of Ca2+ concentration in the cell. This oscillation is called Ca2+ wave and its propagation within the cells has been suggested to control various physiological functions. For example, glial cells in a neural system mutually communicate together by the electronical or the chemical waves. Our object is to clarify whether the Ca2+ waves arise when cells are exposed to an ionizing radiation to regulate their stress responses. We tried to establish an experimental method to visualize the Ca2+ concentration in the various mammalian cells. The cells were treated with a Ca2+ specific chemical fluorescent probe, Fluo 4. Time lapse observations were performed for the cells using a fluorescent microscope. In addition to background fluorescence, a progressive increase or a temporal burst-like Ca2+ concentration-change was seen in some of the cells exposed to X-rays. In conclusion, waves of chemical concentration change of specific signal molecules such as Ca2+ ions might play an important role in communications between not only cells but also organelles in response to radiation stress. ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第63回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Ami"}],"nameIdentifiers":[{"nameIdentifier":"894833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoya, Akinari"}],"nameIdentifiers":[{"nameIdentifier":"894834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Ami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"894835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoya, Akinari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"894836","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Ca2+ waves as stress signals in X-irradiated cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ca2+ waves as stress signals in X-irradiated cells"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-13"},"publish_date":"2020-10-13","publish_status":"0","recid":"80774","relation_version_is_last":true,"title":["Ca2+ waves as stress signals in X-irradiated cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:24:33.335855+00:00"}