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The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication
https://repo.qst.go.jp/records/80635
https://repo.qst.go.jp/records/80635b24d9da4-374c-4a7f-bd0b-25fb3fe5b3ed
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2020-10-05 | |||||
タイトル | ||||||
タイトル | The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
鈴木, 雅雄
× 鈴木, 雅雄× Suzuki, Masao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The last year we reported the enhancement of cell-killing effect irradiated with carbon ions by applying longitudinal magnetic field. This year we examined the mechanism of the effect, focusing on cellular response(s) via gap-junction mediated cell-cell communication. Normal human skin fibroblasts and cervical epitheloid carcinoma cells were irradiated with carbon ions (350MeV/n, LET~12keV/µm) accelerated with the Heavy Ion Medical Accelerator in Chiba under the longitudinal magnetic field (0.6T) with or without a specific inhibitor of gap junction (40 µM of gamma-isomer of hexachloro-cyclohexane). The cell-killing effects treated with the magnetic field were 1.3 ~ 1.5 times higher than those of carbon ion alone. When using the gap-junction inhibitor, the cell-killing effects were enhanced as the same level among the magnetic field alone, the gap-junction inhibitor alone and both treatments. There is evidence that the enhanced effect by the longitudinal magnetic fields is induced by cellular response(s) via gap-junction mediated cell-cell communication. (This is the co-operative study with Drs.T.Inaniwa, N.Usami, S.Sato, A.Noda, M.Muramatsu, Y.Iwata, N.Kanematsu, T.Shirai, K.Noda) | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第79回日本癌学会学術総会 | |||||
発表年月日 | ||||||
日付 | 2020-10-01 | |||||
日付タイプ | Issued |