{"created":"2023-05-15T14:59:25.896173+00:00","id":80635,"links":{},"metadata":{"_buckets":{"deposit":"5ee0d8f0-0ce5-4ce5-a335-9d93323013ac"},"_deposit":{"created_by":1,"id":"80635","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80635"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080635","sets":["10:28"]},"author_link":["890616","890617"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-10-01","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The last year we reported the enhancement of cell-killing effect irradiated with carbon ions by applying longitudinal magnetic field. This year we examined the mechanism of the effect, focusing on cellular response(s) via gap-junction mediated cell-cell communication. Normal human skin fibroblasts and cervical epitheloid carcinoma cells were irradiated with carbon ions (350MeV/n, LET~12keV/µm) accelerated with the Heavy Ion Medical Accelerator in Chiba under the longitudinal magnetic field (0.6T) with or without a specific inhibitor of gap junction (40 µM of gamma-isomer of hexachloro-cyclohexane). The cell-killing effects treated with the magnetic field were 1.3 ~ 1.5 times higher than those of carbon ion alone. When using the gap-junction inhibitor, the cell-killing effects were enhanced as the same level among the magnetic field alone, the gap-junction inhibitor alone and both treatments. There is evidence that the enhanced effect by the longitudinal magnetic fields is induced by cellular response(s) via gap-junction mediated cell-cell communication. (This is the co-operative study with Drs.T.Inaniwa, N.Usami, S.Sato, A.Noda, M.Muramatsu, Y.Iwata, N.Kanematsu, T.Shirai, K.Noda)","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第79回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 雅雄"}],"nameIdentifiers":[{"nameIdentifier":"890616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"890617","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-05"},"publish_date":"2020-10-05","publish_status":"0","recid":"80635","relation_version_is_last":true,"title":["The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:29:46.792988+00:00"}