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Quantitative analysis of dynamic changes in nuclear morphology in cells migrating on microstructured gelatin hydrogel
https://repo.qst.go.jp/records/80578
https://repo.qst.go.jp/records/805785678991b-1266-430b-8dee-3f274c21a8c0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-07-15 | |||||
| タイトル | ||||||
| タイトル | Quantitative analysis of dynamic changes in nuclear morphology in cells migrating on microstructured gelatin hydrogel | |||||
| タイトル | ||||||
| タイトル | マイクロ構造化ハイドロゲル上を移動する細胞の核形態変化の定量解析 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
石田亮
× 石田亮× 大山, 智子× 大山, 廣太郎× 田口, 光正× 三好洋美× Oyama, Tomoko× Oyama, Kotaro× Taguchi, Mitsumasa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The physical properties of cell culture substrate affect various cellular processes, such as migration, proliferation and differentiation. The signaling involves the physical network structure from cell adhesion structure via actin fibers to cell nucleus. To understand the signaling mechanism of mechanotransduction, we focused on the dynamic changes in the morphology of the nucleus, based on the hypothesis that the magnitude and direction of the forces transmitted to the nucleus will change dynamically with actin reorganization in migrating cells. We analyzed the morphological changes of the nucleus in fibroblasts migrating on gelatin hydrogel substrates with micro-pillar and hole arrays and estimated the mechanical effect on the cell nucleus. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第58回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-09-16 | |||||
| 日付タイプ | Issued | |||||
