@misc{oai:repo.qst.go.jp:00080578, author = {石田亮 and 大山, 智子 and 大山, 廣太郎 and 田口, 光正 and 三好洋美 and Oyama, Tomoko and Oyama, Kotaro and Taguchi, Mitsumasa}, month = {Sep}, note = {The physical properties of cell culture substrate affect various cellular processes, such as migration, proliferation and differentiation. The signaling involves the physical network structure from cell adhesion structure via actin fibers to cell nucleus. To understand the signaling mechanism of mechanotransduction, we focused on the dynamic changes in the morphology of the nucleus, based on the hypothesis that the magnitude and direction of the forces transmitted to the nucleus will change dynamically with actin reorganization in migrating cells. We analyzed the morphological changes of the nucleus in fibroblasts migrating on gelatin hydrogel substrates with micro-pillar and hole arrays and estimated the mechanical effect on the cell nucleus., 第58回日本生物物理学会年会}, title = {Quantitative analysis of dynamic changes in nuclear morphology in cells migrating on microstructured gelatin hydrogel}, year = {2020} }