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Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation
https://repo.qst.go.jp/records/80119
https://repo.qst.go.jp/records/80119abc9fb8b-fe0d-4109-8d84-5c8abe692711
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-25 | |||||
| タイトル | ||||||
| タイトル | Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tachibana, Hirotaka
× Tachibana, Hirotaka× Morioka, Takamitsu× Daino, Kazuhiro× Shang, Yi× Ogawa, Mari× Fujita, Misuzu× Matsuura, Akira× Shimada, Yoshiya× Kakinuma, Shizuko× Hirotaka, Tachibana× Takamitsu, Morioka× Kazuhiro, Daino× Yi, Shang× Mari, Ogawa× Misuzu, Fujita× Yoshiya, Shimada× Shizuko, Kakinuma |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Epidemiological studies of atomic-bomb survivors have revealed an increased risk of lymphoid neoplasm (i.e. acute lymphoblastic leukemia) associated with radiation exposure. In particular, children are more susceptible to radiation-induced precursor lymphoid neoplasm than adults. Although about 75% of human lymphoid tumors are B-cell neoplasms, the carcinogenic risk associated with each stage of differentiation of B-cells after radiation exposure is poorly understood. Therefore, we irradiated mice at infancy or in young adulthood to investigate the effect of age at exposure on the risk of developing B-cell neoplasms. Histopathology was used to confirm the presence of lymphoid neoplasms, and the population of B-cell neoplasms was classified into the precursor B-cell (pro-B and pre-B cell) type and mature B-cell type, according to immunophenotype. The data revealed that precursor B-cell neoplasms were induced soon after radiation exposure in infancy or young adulthood, resulting in a greater risk of developing the neoplasms. This was particularly the case for the pro-B cell type after young adult exposure. Our findings suggest that exposure to radiation at young age increases the risk of developing precursor B-cell neoplasms in humans. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 61, 号 5, p. 648-656, 発行日 2020-08 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32808021 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rraa055 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/jrr/article/61/5/648/5893465 | |||||
