{"created":"2023-05-15T14:59:03.264930+00:00","id":80119,"links":{},"metadata":{"_buckets":{"deposit":"842a3043-d87d-4602-95e1-41de1764b8d3"},"_deposit":{"created_by":1,"id":"80119","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80119"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080119","sets":["1"]},"author_link":["943349","943350","943344","943339","943342","943337","943343","943338","943346","943345","943335","943341","943347","943334","943336","943348","943340"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"656","bibliographicPageStart":"648","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research　"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epidemiological studies of atomic-bomb survivors have revealed an increased risk of lymphoid neoplasm (i.e. acute lymphoblastic leukemia) associated with radiation exposure. In particular, children are more susceptible to radiation-induced precursor lymphoid neoplasm than adults. Although about 75% of human lymphoid tumors are B-cell neoplasms, the carcinogenic risk associated with each stage of differentiation of B-cells after radiation exposure is poorly understood. Therefore, we irradiated mice at infancy or in young adulthood to investigate the effect of age at exposure on the risk of developing B-cell neoplasms. Histopathology was used to confirm the presence of lymphoid neoplasms, and the population of B-cell neoplasms was classified into the precursor B-cell (pro-B and pre-B cell) type and mature B-cell type, according to immunophenotype. The data revealed that precursor B-cell neoplasms were induced soon after radiation exposure in infancy or young adulthood, resulting in a greater risk of developing the neoplasms. This was particularly the case for the pro-B cell type after young adult exposure. Our findings suggest that exposure to radiation at young age increases the risk of developing precursor B-cell neoplasms in humans.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32808021","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rraa055","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/jrr/article/61/5/648/5893465","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tachibana, Hirotaka"}],"nameIdentifiers":[{"nameIdentifier":"943334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morioka, Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"943335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daino, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"943336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"943337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Mari"}],"nameIdentifiers":[{"nameIdentifier":"943338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Misuzu"}],"nameIdentifiers":[{"nameIdentifier":"943339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuura, Akira"}],"nameIdentifiers":[{"nameIdentifier":"943340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"943341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"943342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirotaka, Tachibana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamitsu, Morioka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhiro, Daino","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yi, Shang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mari, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Misuzu, Fujita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshiya, Shimada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shizuko, Kakinuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943350","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-25"},"publish_date":"2020-06-25","publish_status":"0","recid":"80119","relation_version_is_last":true,"title":["Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:18:19.056814+00:00"}