@article{oai:repo.qst.go.jp:00080119,
 author = {Tachibana, Hirotaka and Morioka, Takamitsu and Daino, Kazuhiro and Shang, Yi and Ogawa, Mari and Fujita, Misuzu and Matsuura, Akira and Shimada, Yoshiya and Kakinuma, Shizuko and Hirotaka, Tachibana and Takamitsu, Morioka and Kazuhiro, Daino and Yi, Shang and Mari, Ogawa and Misuzu, Fujita and Yoshiya, Shimada and Shizuko, Kakinuma},
 issue = {5},
 journal = {Journal of Radiation Research},
 month = {Aug},
 note = {Epidemiological studies of atomic-bomb survivors have revealed an increased risk of lymphoid neoplasm (i.e. acute lymphoblastic leukemia) associated with radiation exposure. In particular, children are more susceptible to radiation-induced precursor lymphoid neoplasm than adults. Although about 75% of human lymphoid tumors are B-cell neoplasms, the carcinogenic risk associated with each stage of differentiation of B-cells after radiation exposure is poorly understood. Therefore, we irradiated mice at infancy or in young adulthood to investigate the effect of age at exposure on the risk of developing B-cell neoplasms. Histopathology was used to confirm the presence of lymphoid neoplasms, and the population of B-cell neoplasms was classified into the precursor B-cell (pro-B and pre-B cell) type and mature B-cell type, according to immunophenotype. The data revealed that precursor B-cell neoplasms were induced soon after radiation exposure in infancy or young adulthood, resulting in a greater risk of developing the neoplasms. This was particularly the case for the pro-B cell type after young adult exposure. Our findings suggest that exposure to radiation at young age increases the risk of developing precursor B-cell neoplasms in humans.},
 pages = {648--656},
 title = {Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation},
 volume = {61},
 year = {2020}
}