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Validation of Geant4 for silicon microdosimetry in heavy ion therapy
https://repo.qst.go.jp/records/79613
https://repo.qst.go.jp/records/79613826a7b89-6b29-4dc9-bd47-a8b1283fbed2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-23 | |||||
| タイトル | ||||||
| タイトル | Validation of Geant4 for silicon microdosimetry in heavy ion therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
BOLST, David
× BOLST, David× Guatelli, Susanna× Linh Tran, Thuy× Lachlan, Chartier× Davis, Jeremy× Biasi, G.× Prokopovich, Anthony× Pogossov, A.× Reinhard, M.× Petasecca, Marco× Lerch, Michael× Matsufuji, Naruhiro× Povoli, M.× Summanwar, A.× Kok, A.× Jackson, M.× Anatoly, Rozenfeld× BOLST, David× Linh Tran, Thuy× Lachlan, Chartier× Davis, Jeremy× Prokopovich, Anthony× Petasecca, Marco× Lerch, Michael× Naruhiro, Matsufuji× Rozenfeld, Anatoly |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Microdosimetry is a particularly powerful method to estimate the relative biological effectiveness (RBE) of any mixed radiation field. This is particularly convenient for therapeutic heavy ion therapy (HIT) beams, referring to ions larger than protons, where the RBE of the beam can vary significantly along the Bragg curve. Additionally, due to the sharp dose gradients at the end of the Bragg peak (BP), or spread out BP, to make accurate measurements and estimations of the biological properties of a beam a high spatial resolution is required, less than a millimetre. This requirement makes silicon microdosimetry particularly attractive due to the thicknesses of the sensitive volumes commonly being ∼10 µm or less. Monte Carlo (MC) codes are widely used to study the complex mixed HIT radiation field as well as to model the response of novel microdosimeter detectors when irradiated with HIT beams. Therefore it is essential to validate MC codes against experimental measurements. This work compares measurements performed with a silicon microdosimeter in mono-energetic 12C, 14N and 16O ion beams of therapeutic energies, against simulation results calculated with the Geant4 toolkit. Experimental and simulation results were compared in terms of microdosimetric spectra (dose lineal energy, d(y)), the dose mean lineal energy, yD and the RBE10, as estimated by the microdosimetric kinetic model (MKM). Overall Geant4 showed reasonable agreement with experimental measurements. Before the distal edge of the BP, simulation and experiment agreed within ∼10% for yD and ∼2% for RBE10. Downstream of the BP less agreement was observed between simulation and experiment, particularly for the 12C and 16O beams. Simulation results downstream of the BP had lower values of yD and RBE10 compared to the experiment due to a higher contribution from lighter fragments compared to heavier fragments. |
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| 書誌情報 |
Physics in Medicine & Biology 巻 65, 号 4, p. 045014, 発行日 2020-03 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/ab586a | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://iopscience.iop.org/article/10.1088/1361-6560/ab586a | |||||
