@article{oai:repo.qst.go.jp:00079613,
 author = {BOLST, David and Guatelli, Susanna and Linh Tran, Thuy and Lachlan, Chartier and Davis, Jeremy and Biasi, G. and Prokopovich, Anthony and Pogossov, A. and Reinhard, M. and Petasecca, Marco and Lerch, Michael and Matsufuji, Naruhiro and Povoli, M. and Summanwar, A. and Kok, A. and Jackson, M. and Anatoly, Rozenfeld and BOLST, David and Linh Tran, Thuy and Lachlan, Chartier and Davis, Jeremy and Prokopovich, Anthony and Petasecca, Marco and Lerch, Michael and Naruhiro, Matsufuji and Rozenfeld, Anatoly},
 issue = {4},
 journal = {Physics in Medicine & Biology},
 month = {Mar},
 note = {Microdosimetry is a particularly powerful method to estimate the relative biological effectiveness
(RBE) of any mixed radiation field. This is particularly convenient for therapeutic heavy ion therapy
(HIT) beams, referring to ions larger than protons, where the RBE of the beam can vary significantly
along the Bragg curve. Additionally, due to the sharp dose gradients at the end of the Bragg peak (BP),
or spread out BP, to make accurate measurements and estimations of the biological properties of
a beam a high spatial resolution is required, less than a millimetre. This requirement makes silicon
microdosimetry particularly attractive due to the thicknesses of the sensitive volumes commonly
being ∼10 µm or less. Monte Carlo (MC) codes are widely used to study the complex mixed HIT
radiation field as well as to model the response of novel microdosimeter detectors when irradiated
with HIT beams. Therefore it is essential to validate MC codes against experimental measurements.
This work compares measurements performed with a silicon microdosimeter in mono-energetic 12C, 14N and 16O ion beams of therapeutic energies, against simulation results calculated with the
Geant4 toolkit. Experimental and simulation results were compared in terms of microdosimetric
spectra (dose lineal energy, d(y)), the dose mean lineal energy, yD and the RBE10, as estimated by
the microdosimetric kinetic model (MKM). Overall Geant4 showed reasonable agreement with
experimental measurements. Before the distal edge of the BP, simulation and experiment agreed
within ∼10% for yD and ∼2% for RBE10. Downstream of the BP less agreement was observed
between simulation and experiment, particularly for the 12C and 16O beams. Simulation results
downstream of the BP had lower values of yD and RBE10 compared to the experiment due to a higher
contribution from lighter fragments compared to heavier fragments.},
 title = {Validation of Geant4 for silicon microdosimetry in heavy ion therapy},
 volume = {65},
 year = {2020}
}