{"created":"2023-05-15T14:58:40.959991+00:00","id":79613,"links":{},"metadata":{"_buckets":{"deposit":"f8b05df3-f125-4975-ba26-be78c1bd8d49"},"_deposit":{"created_by":1,"id":"79613","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79613"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079613","sets":["1"]},"author_link":["999908","999910","999899","999900","999919","999902","999897","999922","999901","999903","999920","999905","999914","999911","999916","999906","999921","999904","999915","999917","999898","999909","999907","999912","999913","999918"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"045014","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Physics in Medicine & Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Microdosimetry is a particularly powerful method to estimate the relative biological effectiveness\n(RBE) of any mixed radiation field. This is particularly convenient for therapeutic heavy ion therapy\n(HIT) beams, referring to ions larger than protons, where the RBE of the beam can vary significantly\nalong the Bragg curve. Additionally, due to the sharp dose gradients at the end of the Bragg peak (BP),\nor spread out BP, to make accurate measurements and estimations of the biological properties of\na beam a high spatial resolution is required, less than a millimetre. This requirement makes silicon\nmicrodosimetry particularly attractive due to the thicknesses of the sensitive volumes commonly\nbeing ∼10 µm or less. Monte Carlo (MC) codes are widely used to study the complex mixed HIT\nradiation field as well as to model the response of novel microdosimeter detectors when irradiated\nwith HIT beams. Therefore it is essential to validate MC codes against experimental measurements.\nThis work compares measurements performed with a silicon microdosimeter in mono-energetic 12C, 14N and 16O ion beams of therapeutic energies, against simulation results calculated with the\nGeant4 toolkit. Experimental and simulation results were compared in terms of microdosimetric\nspectra (dose lineal energy, d(y)), the dose mean lineal energy, yD and the RBE10, as estimated by\nthe microdosimetric kinetic model (MKM). Overall Geant4 showed reasonable agreement with\nexperimental measurements. Before the distal edge of the BP, simulation and experiment agreed\nwithin ∼10% for yD and ∼2% for RBE10. Downstream of the BP less agreement was observed\nbetween simulation and experiment, particularly for the 12C and 16O beams. Simulation results\ndownstream of the BP had lower values of yD and RBE10 compared to the experiment due to a higher\ncontribution from lighter fragments compared to heavier fragments.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IOP Publishing"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1088/1361-6560/ab586a","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://iopscience.iop.org/article/10.1088/1361-6560/ab586a","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-9155","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"BOLST, David"}],"nameIdentifiers":[{"nameIdentifier":"999897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Guatelli, Susanna"}],"nameIdentifiers":[{"nameIdentifier":"999898","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Linh Tran, Thuy"}],"nameIdentifiers":[{"nameIdentifier":"999899","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lachlan, Chartier"}],"nameIdentifiers":[{"nameIdentifier":"999900","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Davis, Jeremy"}],"nameIdentifiers":[{"nameIdentifier":"999901","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Biasi, G."}],"nameIdentifiers":[{"nameIdentifier":"999902","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Prokopovich, Anthony"}],"nameIdentifiers":[{"nameIdentifier":"999903","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Pogossov, A."}],"nameIdentifiers":[{"nameIdentifier":"999904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Reinhard, M."}],"nameIdentifiers":[{"nameIdentifier":"999905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Petasecca, Marco"}],"nameIdentifiers":[{"nameIdentifier":"999906","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lerch, Michael"}],"nameIdentifiers":[{"nameIdentifier":"999907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro"}],"nameIdentifiers":[{"nameIdentifier":"999908","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Povoli, M."}],"nameIdentifiers":[{"nameIdentifier":"999909","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Summanwar, A."}],"nameIdentifiers":[{"nameIdentifier":"999910","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kok, A."}],"nameIdentifiers":[{"nameIdentifier":"999911","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jackson, M."}],"nameIdentifiers":[{"nameIdentifier":"999912","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anatoly, Rozenfeld"}],"nameIdentifiers":[{"nameIdentifier":"999913","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"BOLST, David","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999914","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Linh Tran, Thuy","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999915","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lachlan, Chartier","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Davis, Jeremy","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999917","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Prokopovich, Anthony","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999918","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Petasecca, Marco","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lerch, Michael","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruhiro, Matsufuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rozenfeld, Anatoly","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999922","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Validation of Geant4 for silicon microdosimetry in heavy ion therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Validation of Geant4 for silicon microdosimetry in heavy ion therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-23"},"publish_date":"2020-03-23","publish_status":"0","recid":"79613","relation_version_is_last":true,"title":["Validation of Geant4 for silicon microdosimetry in heavy ion therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:43:19.137313+00:00"}