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An irradiation device for biological targets using focused microbeams of cyclotron-accelerated heavy ion
https://repo.qst.go.jp/records/78896
https://repo.qst.go.jp/records/788960713d1c7-131a-40b1-9b69-e16c56531dc0
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-01-07 | |||||
タイトル | ||||||
タイトル | An irradiation device for biological targets using focused microbeams of cyclotron-accelerated heavy ion | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Funayama, Tomoo
× Funayama, Tomoo× Sakashita, Tetsuya× Suzuki, Michiyo× Yokota, Yuichiro× Miyawaki, Nobumasa× Kashiwagi, Hirotsugu× Satoh, Takahiro× Kurashima, Satoshi× Tomo, Funayama× Tetsuya, Sakashita× Michiyo, Suzuki× Yuuichiro, Yokota× Nobumasa, Miyawaki× Hirotsugu, Kashiwagi× Takahiro, Satoh× Satoshi, Kurashima |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For use in medical and life science research, a device and sample preparation methods were developed to irradiate cultured cells and individual animals with a focused microbeam of cyclotron-accelerated heavy-ions. The new irradiation device positions both sample and microscope with micrometer precision. The beam size is smaller than 3 μm when the distance between the beam exit from vacuum to the irradiation device is less than 500 μm for 13.0 MeV/n 20Ne ions. This beam size is sufficiently small to irradiate intracellular targets in cultured cells. A beam size smaller than 10 μm was obtained for 12C ions of 26.7 MeV/n at a distance of 2 mm from the beam exit, which enabled irradiation of specific cells in a small model animal. Methods to prepare cultured cells and the nematode Caenorhabditis elegans for irradiation using the new device are reported, and the results of the first irradiation experiments presented. | |||||
書誌情報 |
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 巻 465, p. 101-109, 発行日 2020-01 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0168-583X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.nimb.2019.12.028 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0168583X1930847X |
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Cite as
Funayama, Tomoo, Sakashita, Tetsuya, Suzuki, Michiyo, Yokota, Yuichiro, Miyawaki, Nobumasa, Kashiwagi, Hirotsugu, Satoh, Takahiro, Kurashima, Satoshi, Tomo, Funayama, Tetsuya, Sakashita, Michiyo, Suzuki, Yuuichiro, Yokota, Nobumasa, Miyawaki, Hirotsugu, Kashiwagi, Takahiro, Satoh, Satoshi, Kurashima, 2020, An irradiation device for biological targets using focused microbeams of cyclotron-accelerated heavy ion: Elsevier, 101–109 p.
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