{"_buckets": {"deposit": "b6b8b543-dd7a-47de-9ee1-8f1553fc7481"}, "_deposit": {"created_by": 1, "id": "78509", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "78509"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00078509", "sets": ["1"]}, "author_link": ["1064434", "1064435", "1064427", "1064437", "1064433", "1064442", "1064438", "1064424", "1064429", "1064428", "1064430", "1064426", "1064422", "1064431", "1064439", "1064441", "1064440", "1064425", "1064421", "1064423", "1064436", "1064432"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "197", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "Nature communications"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has remained elusive however, which is a considerable impediment to their potential medical application. Here we report a specific stage at which iPSC generation is not reduced in response to ionizing radiation, i.e. radio-resistance. Quite intriguingly, a G1/S cell cycle checkpoint deficiency occurs in a transient fashion at the initial stage of the genome reprogramming process. These cancer-like phenomena, i.e. a cell cycle checkpoint deficiency resulting in the accumulation of point mutations, suggest a common developmental pathway between iPSC generation and tumorigenesis. This notion is supported by the identification of specific cancer mutational signatures in these cells. We describe efficient generation of human integration-free iPSCs using erythroblast cells, which have only a small number of point mutations and INDELs, none of which are in coding regions.", "subitem_description_type": "Abstract"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "31924765", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s41467-019-13830-x", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s41467-019-13830-x", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2041-1723", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Araki, Ryoko"}], "nameIdentifiers": [{"nameIdentifier": "1064421", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hoki, Yuko"}], "nameIdentifiers": [{"nameIdentifier": "1064422", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suga, Tomo"}], "nameIdentifiers": [{"nameIdentifier": "1064423", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Obara, Chizuka"}], "nameIdentifiers": [{"nameIdentifier": "1064424", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sunayama, Misato"}], "nameIdentifiers": [{"nameIdentifier": "1064425", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imadome, Kaori"}], "nameIdentifiers": [{"nameIdentifier": "1064426", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujita, Mayumi"}], "nameIdentifiers": [{"nameIdentifier": "1064427", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamimura, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "1064428", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Miki"}], "nameIdentifiers": [{"nameIdentifier": "1064429", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakayama, Sayaka"}], "nameIdentifiers": [{"nameIdentifier": "1064430", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagy, Andras"}], "nameIdentifiers": [{"nameIdentifier": "1064431", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakayama, Teruhiko"}], "nameIdentifiers": [{"nameIdentifier": "1064432", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abe, Masumi"}], "nameIdentifiers": [{"nameIdentifier": "1064433", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ryoko, Araki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064434", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yuko, Fujimori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064435", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomo, Suga", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064436", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chizuka, Obara", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064437", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Misato, Sunayama", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064438", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaori, Imadome", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mayumi, Fujita", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064440", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Satoshi, Kamimura", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064441", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masumi, Abe", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1064442", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/78509", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-01-22"}, "publish_date": "2020-01-22", "publish_status": "0", "recid": "78509", "relation": {}, "relation_version_is_last": true, "title": ["Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency."], "weko_shared_id": -1}