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  1. 原著論文

Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.

https://repo.qst.go.jp/records/78509
https://repo.qst.go.jp/records/78509
5db9e705-4b24-40ed-9069-5358d9c292a9
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-01-22
タイトル
タイトル Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Araki, Ryoko

× Araki, Ryoko

WEKO 1064421

Araki, Ryoko

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Hoki, Yuko

× Hoki, Yuko

WEKO 1064422

Hoki, Yuko

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Suga, Tomo

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WEKO 1064423

Suga, Tomo

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Obara, Chizuka

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WEKO 1064424

Obara, Chizuka

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Sunayama, Misato

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WEKO 1064425

Sunayama, Misato

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Imadome, Kaori

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WEKO 1064426

Imadome, Kaori

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Fujita, Mayumi

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WEKO 1064427

Fujita, Mayumi

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Kamimura, Satoshi

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WEKO 1064428

Kamimura, Satoshi

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Nakamura, Miki

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WEKO 1064429

Nakamura, Miki

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Wakayama, Sayaka

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WEKO 1064430

Wakayama, Sayaka

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Nagy, Andras

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WEKO 1064431

Nagy, Andras

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Wakayama, Teruhiko

× Wakayama, Teruhiko

WEKO 1064432

Wakayama, Teruhiko

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Abe, Masumi

× Abe, Masumi

WEKO 1064433

Abe, Masumi

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Ryoko, Araki

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WEKO 1064434

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Yuko, Fujimori

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WEKO 1064435

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Tomo, Suga

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WEKO 1064436

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Chizuka, Obara

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WEKO 1064437

en Chizuka, Obara

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Misato, Sunayama

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WEKO 1064438

en Misato, Sunayama

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Kaori, Imadome

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WEKO 1064439

en Kaori, Imadome

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Mayumi, Fujita

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WEKO 1064440

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Satoshi, Kamimura

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WEKO 1064441

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Masumi, Abe

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WEKO 1064442

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抄録
内容記述タイプ Abstract
内容記述 A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has remained elusive however, which is a considerable impediment to their potential medical application. Here we report a specific stage at which iPSC generation is not reduced in response to ionizing radiation, i.e. radio-resistance. Quite intriguingly, a G1/S cell cycle checkpoint deficiency occurs in a transient fashion at the initial stage of the genome reprogramming process. These cancer-like phenomena, i.e. a cell cycle checkpoint deficiency resulting in the accumulation of point mutations, suggest a common developmental pathway between iPSC generation and tumorigenesis. This notion is supported by the identification of specific cancer mutational signatures in these cells. We describe efficient generation of human integration-free iPSCs using erythroblast cells, which have only a small number of point mutations and INDELs, none of which are in coding regions.
書誌情報 Nature communications

巻 11, 号 1, p. 197, 発行日 2020-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 2041-1723
PubMed番号
識別子タイプ PMID
関連識別子 31924765
DOI
識別子タイプ DOI
関連識別子 10.1038/s41467-019-13830-x
関連サイト
識別子タイプ URI
関連識別子 https://www.nature.com/articles/s41467-019-13830-x
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