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Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
https://repo.qst.go.jp/records/78509
https://repo.qst.go.jp/records/785095db9e705-4b24-40ed-9069-5358d9c292a9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-22 | |||||
| タイトル | ||||||
| タイトル | Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Araki, Ryoko
× Araki, Ryoko× Hoki, Yuko× Suga, Tomo× Obara, Chizuka× Sunayama, Misato× Imadome, Kaori× Fujita, Mayumi× Kamimura, Satoshi× Nakamura, Miki× Wakayama, Sayaka× Nagy, Andras× Wakayama, Teruhiko× Abe, Masumi× Ryoko, Araki× Yuko, Fujimori× Tomo, Suga× Chizuka, Obara× Misato, Sunayama× Kaori, Imadome× Mayumi, Fujita× Satoshi, Kamimura× Masumi, Abe |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has remained elusive however, which is a considerable impediment to their potential medical application. Here we report a specific stage at which iPSC generation is not reduced in response to ionizing radiation, i.e. radio-resistance. Quite intriguingly, a G1/S cell cycle checkpoint deficiency occurs in a transient fashion at the initial stage of the genome reprogramming process. These cancer-like phenomena, i.e. a cell cycle checkpoint deficiency resulting in the accumulation of point mutations, suggest a common developmental pathway between iPSC generation and tumorigenesis. This notion is supported by the identification of specific cancer mutational signatures in these cells. We describe efficient generation of human integration-free iPSCs using erythroblast cells, which have only a small number of point mutations and INDELs, none of which are in coding regions. | |||||
| 書誌情報 |
Nature communications 巻 11, 号 1, p. 197, 発行日 2020-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31924765 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41467-019-13830-x | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41467-019-13830-x | |||||
