{"created":"2023-05-15T14:57:52.676178+00:00","id":78509,"links":{},"metadata":{"_buckets":{"deposit":"b6b8b543-dd7a-47de-9ee1-8f1553fc7481"},"_deposit":{"created_by":1,"id":"78509","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78509"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078509","sets":["1"]},"author_link":["1064434","1064435","1064427","1064437","1064433","1064442","1064438","1064424","1064429","1064428","1064430","1064426","1064422","1064431","1064439","1064441","1064440","1064425","1064421","1064423","1064436","1064432"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"197","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Nature communications"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has remained elusive however, which is a considerable impediment to their potential medical application. Here we report a specific stage at which iPSC generation is not reduced in response to ionizing radiation, i.e. radio-resistance. Quite intriguingly, a G1/S cell cycle checkpoint deficiency occurs in a transient fashion at the initial stage of the genome reprogramming process. These cancer-like phenomena, i.e. a cell cycle checkpoint deficiency resulting in the accumulation of point mutations, suggest a common developmental pathway between iPSC generation and tumorigenesis. This notion is supported by the identification of specific cancer mutational signatures in these cells. We describe efficient generation of human integration-free iPSCs using erythroblast cells, which have only a small number of point mutations and INDELs, none of which are in coding regions.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31924765","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41467-019-13830-x","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-019-13830-x","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Araki, Ryoko"}],"nameIdentifiers":[{"nameIdentifier":"1064421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hoki, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"1064422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Tomo"}],"nameIdentifiers":[{"nameIdentifier":"1064423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Obara, Chizuka"}],"nameIdentifiers":[{"nameIdentifier":"1064424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunayama, Misato"}],"nameIdentifiers":[{"nameIdentifier":"1064425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imadome, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"1064426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"1064427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamimura, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"1064428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Miki"}],"nameIdentifiers":[{"nameIdentifier":"1064429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakayama, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"1064430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagy, Andras"}],"nameIdentifiers":[{"nameIdentifier":"1064431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakayama, Teruhiko"}],"nameIdentifiers":[{"nameIdentifier":"1064432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Masumi"}],"nameIdentifiers":[{"nameIdentifier":"1064433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryoko, Araki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuko, Fujimori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064435","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomo, Suga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chizuka, Obara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Misato, Sunayama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaori, Imadome","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mayumi, Fujita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Satoshi, Kamimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masumi, Abe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1064442","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"78509","relation_version_is_last":true,"title":["Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T16:48:36.510296+00:00"}