@article{oai:repo.qst.go.jp:00078509,
 author = {Araki, Ryoko and Hoki, Yuko and Suga, Tomo and Obara, Chizuka and Sunayama, Misato and Imadome, Kaori and Fujita, Mayumi and Kamimura, Satoshi and Nakamura, Miki and Wakayama, Sayaka and Nagy, Andras and Wakayama, Teruhiko and Abe, Masumi and Ryoko, Araki and Yuko, Fujimori and Tomo, Suga and Chizuka, Obara and Misato, Sunayama and Kaori, Imadome and Mayumi, Fujita and Satoshi, Kamimura and Masumi, Abe},
 issue = {1},
 journal = {Nature communications},
 month = {Jan},
 note = {A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has remained elusive however, which is a considerable impediment to their potential medical application. Here we report a specific stage at which iPSC generation is not reduced in response to ionizing radiation, i.e. radio-resistance. Quite intriguingly, a G1/S cell cycle checkpoint deficiency occurs in a transient fashion at the initial stage of the genome reprogramming process. These cancer-like phenomena, i.e. a cell cycle checkpoint deficiency resulting in the accumulation of point mutations, suggest a common developmental pathway between iPSC generation and tumorigenesis. This notion is supported by the identification of specific cancer mutational signatures in these cells. We describe efficient generation of human integration-free iPSCs using erythroblast cells, which have only a small number of point mutations and INDELs, none of which are in coding regions.},
 title = {Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.},
 volume = {11},
 year = {2020}
}