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Changes in Brain Metabolite Concentrations after Neonatal Hypoxic–ischemic Encephalopathy
https://repo.qst.go.jp/records/78444
https://repo.qst.go.jp/records/78444e905ced4-ee07-4fd6-833c-7fd18722f093
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-14 | |||||
| タイトル | ||||||
| タイトル | Changes in Brain Metabolite Concentrations after Neonatal Hypoxic–ischemic Encephalopathy | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
柴崎, 淳
× 柴崎, 淳× 相田, 典子× 森崎, 菜穂× 富安, もよこ× 西, 悠里× 豊島, 勝昭× Aida, Noriko× Tomiyasu, Moyoko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose：To investigate the time-course changes and predictive utility of brain metabolite concentrations in HIE. Materials and Methods：68 neonates with HIE were examined using MRS（TE/TR：30/5000 ms）at 18-96 h（n=25）and 7-14 days（n=64）after birth to estimate metabolite concentrations in the deep gray matter. Adverse outcome was defined as death or neurodevelopmental impairment at 18-22 months of age. AUCs were calculated to evaluate the prognostic values of metabolites. Results：At 18-96 h, NAA and Cre were lower, whereas Lac and Glx were higher in neonates with adverse outcomes than in those with favorable outcomes. Metabolite concentrations at 18-96 h decreased during days 7-14 in neonates with adverse outcomes but did not change in those with favorable outcomes. AUCs for NAA, Cre, Lac, and Glx measured at 18-96 h to predict adverse outcomes were 0.98, 0.89, 0.96, and 0.88, respectively, whereas AUCs at 7-14 days were 0.97, 0.97, 0.59, and 0.36, respectively. Conclusions：Time-dependent reductions in NAA and Cre concentrations at both 18-96 h and 7-14 days accurately predicted adverse outcomes. However, higher levels in Lac and Glx concentrations were often transient. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本小児科学会学術集会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-04-19 | |||||
| 日付タイプ | Issued | |||||
