@misc{oai:repo.qst.go.jp:00078444,
 author = {柴崎, 淳 and 相田, 典子 and 森崎, 菜穂 and 富安, もよこ and 西, 悠里 and 豊島, 勝昭 and Aida, Noriko and Tomiyasu, Moyoko},
 month = {Apr},
 note = {Purpose：To investigate the time-course changes and predictive utility of brain metabolite concentrations in HIE.
Materials and Methods：68 neonates with HIE were examined using MRS（TE/TR：30/5000 ms）at 18-96 h（n=25）and 7-14 days（n=64）after birth to estimate metabolite concentrations in the deep gray matter. Adverse outcome was defined as death or neurodevelopmental impairment at 18-22 months of age. AUCs were calculated to evaluate the prognostic values of metabolites.
Results：At 18-96 h, NAA and Cre were lower, whereas Lac and Glx were higher in neonates with adverse outcomes than in those with favorable outcomes. Metabolite concentrations at 18-96 h decreased during days 7-14 in neonates with adverse outcomes but did not change in those with favorable outcomes. AUCs for NAA, Cre, Lac, and Glx measured at 18-96 h to predict adverse outcomes were 0.98, 0.89, 0.96, and 0.88, respectively, whereas AUCs at 7-14 days were 0.97, 0.97, 0.59, and 0.36, respectively.
Conclusions：Time-dependent reductions in NAA and Cre concentrations at both 18-96 h and 7-14 days accurately predicted adverse outcomes. However, higher levels in Lac and Glx concentrations were often transient., 日本小児科学会学術集会},
 title = {Changes in Brain Metabolite Concentrations after Neonatal Hypoxic–ischemic Encephalopathy},
 year = {2019}
}