{"created":"2023-05-15T14:57:49.502928+00:00","id":78444,"links":{},"metadata":{"_buckets":{"deposit":"6908c281-19d9-4eb0-af21-117f42ea1c9c"},"_deposit":{"created_by":1,"id":"78444","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78444"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078444","sets":["10:27"]},"author_link":["824765","824770","824768","824771","824767","824764","824766","824769"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-04-19","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Purpose：To investigate the time-course changes and predictive utility of brain metabolite concentrations in HIE.\nMaterials and Methods：68 neonates with HIE were examined using MRS（TE/TR：30/5000 ms）at 18-96 h（n=25）and 7-14 days（n=64）after birth to estimate metabolite concentrations in the deep gray matter. Adverse outcome was defined as death or neurodevelopmental impairment at 18-22 months of age. AUCs were calculated to evaluate the prognostic values of metabolites.\nResults：At 18-96 h, NAA and Cre were lower, whereas Lac and Glx were higher in neonates with adverse outcomes than in those with favorable outcomes. Metabolite concentrations at 18-96 h decreased during days 7-14 in neonates with adverse outcomes but did not change in those with favorable outcomes. AUCs for NAA, Cre, Lac, and Glx measured at 18-96 h to predict adverse outcomes were 0.98, 0.89, 0.96, and 0.88, respectively, whereas AUCs at 7-14 days were 0.97, 0.97, 0.59, and 0.36, respectively.\nConclusions：Time-dependent reductions in NAA and Cre concentrations at both 18-96 h and 7-14 days accurately predicted adverse outcomes. However, higher levels in Lac and Glx concentrations were often transient.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本小児科学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柴崎, 淳"}],"nameIdentifiers":[{"nameIdentifier":"824764","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相田, 典子"}],"nameIdentifiers":[{"nameIdentifier":"824765","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森崎, 菜穂"}],"nameIdentifiers":[{"nameIdentifier":"824766","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"富安, もよこ"}],"nameIdentifiers":[{"nameIdentifier":"824767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西, 悠里"}],"nameIdentifiers":[{"nameIdentifier":"824768","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"豊島, 勝昭"}],"nameIdentifiers":[{"nameIdentifier":"824769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aida, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"824770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomiyasu, Moyoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"824771","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Changes in Brain Metabolite Concentrations after Neonatal Hypoxic–ischemic Encephalopathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes in Brain Metabolite Concentrations after Neonatal Hypoxic–ischemic Encephalopathy"}]},"item_type_id":"10005","owner":"1","path":["27"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-14"},"publish_date":"2020-01-14","publish_status":"0","recid":"78444","relation_version_is_last":true,"title":["Changes in Brain Metabolite Concentrations after Neonatal Hypoxic–ischemic Encephalopathy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:12:25.214247+00:00"}