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PET imaging of VEGFR-2 with a novel 64Cu labeled peptide
https://repo.qst.go.jp/records/78133
https://repo.qst.go.jp/records/7813393fd2790-f934-4af2-828c-8c4882e92451
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-09 | |||||
| タイトル | ||||||
| タイトル | PET imaging of VEGFR-2 with a novel 64Cu labeled peptide | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Ming-Rong, Zhang× Kuan, Hu× Ming-Rong, Zhang |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The first-of-its-kind peptide-based VEGFR-2 positron emission tomography (PET) tracer was developed here. [64Cu]VEGF125-136 peptide was successfully obtained with satisfiable radiocharacteristics. The tracer showed good specificity to visualize VEGFR-2 in various mouse models, and the tumor-specific radioactivity uptake was highly correlated to the VEGFR-2 expression level. Moreover, the tracer showed high tumor uptake (5.89 ± 2.58 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 hour after injection. These features endow the [64Cu]VEGF125-136 as a promising clinically translatable PET tracer for imaging tumor angiogenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第19回放射性医薬品・画像診断薬研究会での口頭発表 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-12-30 | |||||
| 日付タイプ | Issued | |||||
