{"created":"2023-05-15T14:57:34.237911+00:00","id":78133,"links":{},"metadata":{"_buckets":{"deposit":"75848f32-ae30-4205-8ef3-ef876721f889"},"_deposit":{"created_by":1,"id":"78133","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78133"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078133","sets":["10:29"]},"author_link":["815967","815966","815968","815965"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-12-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The first-of-its-kind peptide-based VEGFR-2 positron emission tomography (PET) tracer was developed here. [64Cu]VEGF125-136 peptide was successfully obtained with satisfiable radiocharacteristics. The tracer showed good specificity to visualize VEGFR-2 in various mouse models, and the tumor-specific radioactivity uptake was highly correlated to the VEGFR-2 expression level. Moreover, the tracer showed high tumor uptake (5.89 ± 2.58 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 hour after injection. These features endow the [64Cu]VEGF125-136 as a promising clinically translatable PET tracer for imaging tumor angiogenesis.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第19回放射性医薬品・画像診断薬研究会での口頭発表","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"815965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"815966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"815967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"815968","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PET imaging of VEGFR-2 with a novel 64Cu labeled peptide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET imaging of VEGFR-2 with a novel 64Cu labeled peptide"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-09"},"publish_date":"2019-12-09","publish_status":"0","recid":"78133","relation_version_is_last":true,"title":["PET imaging of VEGFR-2 with a novel 64Cu labeled peptide"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:26:24.376001+00:00"}