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Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET
https://repo.qst.go.jp/records/78131
https://repo.qst.go.jp/records/7813145d025fc-cc36-4878-aa0f-394594e88b61
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-20 | |||||
| タイトル | ||||||
| タイトル | Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yu, Qingzhen
× Yu, Qingzhen× Kumata, Katsushi× Li, Hua× Zhang, Yiding× Chen, Zhen× Zhang, Xiaofei× Shao, Tuo× Hatori, Akiko× Yamasaki, Tomoteru× Xie, Lin× Kuan, Hu× Wang, Gangqiag× Josephson, Lee× Sun, Shaofa× Ming-Rong, Zhang× Liang, Huan× Katsushi, Kumata× Zhang, Yiding× Akiko, Hatori× Tomoteru, Yamasaki× Lin, Xie× Kuan, Hu× Zhang, Ming-Rong× Liang, Huan |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Transmembrane AMPA receptor regulatory proteins (TARPs) are a recently discovered family of proteins that modulate AMPA receptors activity. Based on a potent and selective TARP subtype γ-8 antagonist, 6-(methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one (compound 9), we perform the radiosynthesis of its 11C-isotopologue 1 and conduct preliminary PET evaluation to test the feasibility of imaging TARP γ-8 dependent receptors in vivo. | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 30, 号 4, p. 126879, 発行日 2019-12 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0960-894X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bmcl.2019.126879 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0960894X19308571?via%3Dihub | |||||
