@article{oai:repo.qst.go.jp:00078131, author = {Yu, Qingzhen and Kumata, Katsushi and Li, Hua and Zhang, Yiding and Chen, Zhen and Zhang, Xiaofei and Shao, Tuo and Hatori, Akiko and Yamasaki, Tomoteru and Xie, Lin and Kuan, Hu and Wang, Gangqiag and Josephson, Lee and Sun, Shaofa and Ming-Rong, Zhang and Liang, Huan and Katsushi, Kumata and Zhang, Yiding and Akiko, Hatori and Tomoteru, Yamasaki and Lin, Xie and Kuan, Hu and Zhang, Ming-Rong and Liang, Huan}, issue = {4}, journal = {Bioorganic & Medicinal Chemistry Letters}, month = {Dec}, note = {Transmembrane AMPA receptor regulatory proteins (TARPs) are a recently discovered family of proteins that modulate AMPA receptors activity. Based on a potent and selective TARP subtype γ-8 antagonist, 6-(methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one (compound 9), we perform the radiosynthesis of its 11C-isotopologue 1 and conduct preliminary PET evaluation to test the feasibility of imaging TARP γ-8 dependent receptors in vivo.}, title = {Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET}, volume = {30}, year = {2019} }