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Changes of intracellular environment and autophagy activity during senescence induction after X-ray exposure.
https://repo.qst.go.jp/records/77505
https://repo.qst.go.jp/records/77505f32bd25a-f107-465b-96d7-56c243a999cd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-10-29 | |||||
| タイトル | ||||||
| タイトル | Changes of intracellular environment and autophagy activity during senescence induction after X-ray exposure. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ihara, Tomokazu
× Ihara, Tomokazu× Noguchi, Miho× Yokoya, Akinari× Ihara, Tomokazu× Noguchi, Miho× Yokoya, Akinari |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Autophagy of ionizing irradiated cells is well known to correlated with induction of their senescence, and might also be involved in senescence or carcinogenesis of other cells surrounding them. Those evidences suggest that intracellular environment in senescent cells would be different from that of normal cells. To reveal the intracellular autophagy activities in human fibroblast cells after 20Gy X-ray exposure and to understand the relationship between cell senescence and autophagy, we analyzed the expression level of p16 and p21, which are involved in senescence, and LC3 and pp62, which play a role in autophagy, by western blotting of extract from irradiated cells. The expression level of p16 and p21 gradually increased after irradiation. Although the expression level of LC3 also increased until a few days after exposure, pp62 decreased rapidly. It is inferred that pp62 is necessary for selective autophagy, but be decomposed after the autophagy. For these processes, it might contribute to intracellular homeostasis. These results indicated that selective autophagy could be activated immediately after irradiation, and then, non-selective autophagy could be activated and cause secretion of certain factors inducing late effects, such as carcinogenesis of surrounding cells. For further study, application of a novel technique using nano-diamonds will be discussed in terms of sensing physical parameters, such as temperature, in the senescent cells. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第62回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-11-15 | |||||
| 日付タイプ | Issued | |||||
