{"created":"2023-05-15T14:57:06.993665+00:00","id":77505,"links":{},"metadata":{"_buckets":{"deposit":"875075d7-85a8-459f-a27a-197edeec4b4b"},"_deposit":{"created_by":1,"id":"77505","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77505"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077505","sets":["10:28"]},"author_link":["859967","859966","859970","859969","859968","859965"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Autophagy of ionizing irradiated cells is well known\nto correlated with induction of their senescence, and\nmight also be involved in senescence or carcinogenesis of\nother cells surrounding them. Those evidences suggest\nthat intracellular environment in senescent cells would\nbe different from that of normal cells. To reveal the\nintracellular autophagy activities in human fibroblast\ncells after 20Gy X-ray exposure and to understand the\nrelationship between cell senescence and autophagy,\nwe analyzed the expression level of p16 and p21, which\nare involved in senescence, and LC3 and pp62, which\nplay a role in autophagy, by western blotting of extract\nfrom irradiated cells. The expression level of p16 and\np21 gradually increased after irradiation. Although the\nexpression level of LC3 also increased until a few days\nafter exposure, pp62 decreased rapidly. It is inferred\nthat pp62 is necessary for selective autophagy, but be\ndecomposed after the autophagy. For these processes,\nit might contribute to intracellular homeostasis. These\nresults indicated that selective autophagy could be\nactivated immediately after irradiation, and then,\nnon-selective autophagy could be activated and cause\nsecretion of certain factors inducing late effects, such as\ncarcinogenesis of surrounding cells. For further study,\napplication of a novel technique using nano-diamonds\nwill be discussed in terms of sensing physical parameters, such as temperature, in the senescent cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第62回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ihara, Tomokazu"}],"nameIdentifiers":[{"nameIdentifier":"859965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noguchi, Miho"}],"nameIdentifiers":[{"nameIdentifier":"859966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoya, Akinari"}],"nameIdentifiers":[{"nameIdentifier":"859967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ihara, Tomokazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"859968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noguchi, Miho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"859969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoya, Akinari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"859970","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Changes of intracellular environment and autophagy activity during senescence induction after X-ray exposure.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes of intracellular environment and autophagy activity during senescence induction after X-ray exposure."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-29"},"publish_date":"2019-10-29","publish_status":"0","recid":"77505","relation_version_is_last":true,"title":["Changes of intracellular environment and autophagy activity during senescence induction after X-ray exposure."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:12:10.831358+00:00"}