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放射線研究における超偏極−核磁気共鳴分光法とイメージングの応用
https://repo.qst.go.jp/records/77471
https://repo.qst.go.jp/records/774715aef279a-16bf-4c56-ae32-546def254c84
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-18 | |||||
| タイトル | ||||||
| タイトル | 放射線研究における超偏極−核磁気共鳴分光法とイメージングの応用 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
高草木, 洋一
× 高草木, 洋一× Takakusagi, Yoichi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hyperpolarization is a quantum technology to enhance the sensitivity of nuclear magnetic resonance (NMR). The hyperpolarized (HP) chemical probe, which is a low molecular mass compound labeled with an NMR-positive nuclei like 13C or 15N, is dissolved in a glassing agent (e.g. glycerol/H2O) doped with a stable radical compound (OX063, etc.). The sample mixture is conditioned in a polarizing system (e.g. 3.35 Tesla, -271.6 °C, 2.8 mbar), and irradiation of the unpaired electrons with microwaves (e.g. 94 GHz, 100 mW) transfers the spin polarization from the electrons to the nuclei through the Overhauser effect. Using a superheated solvent (~200 °C), the polarized sample mixture is immediately dissolved by warming up to around biological temperature, and then quickly transferred for NMR/MRI acquisition. The chemical shift change of NMR-positive nuclei, which is induced upon the structural conversion of the HP chemical probe as a tracer, can be observed in real-time depending on the enhanced NMR signals over 4 orders of magnitude (>10,000-fold). Following the development of functional HP chemical probes and surrounding options, this technology is currently being applied to non-invasive NMR spectroscopy for direct monitoring of cell metabolism, MRI metabolic imaging of various disease animal models, and patients with cancer. In this symposium, a brief overview of the HP-NMR/MRI will be presented, focusing on the application in radiation research as well as the current topics and future directions of this technology. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第 62 回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-11-15 | |||||
| 日付タイプ | Issued | |||||
